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Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring.
Susen, Sophie; Tacquard, Charles Ambroise; Godon, Alexandre; Mansour, Alexandre; Garrigue, Delphine; Nguyen, Philippe; Godier, Anne; Testa, Sophie; Levy, Jerrold H; Albaladejo, Pierre; Gruel, Yves.
  • Susen S; Department of Hematology and Transfusion, Lille University Hospital, Lille, France. Sophie.SUSEN@CHRU-LILLE.FR.
  • Tacquard CA; Department of Hemostasis and Transfusion, CHU Lille, Lille, France. Sophie.SUSEN@CHRU-LILLE.FR.
  • Godon A; Department of Anesthesia and Intensive Care, Strasbourg University Hospital, Strasbourg, France.
  • Mansour A; Department of Anesthesiology and Critical Care, Grenoble Alpes University Hospital, La Tronche, France.
  • Garrigue D; Department of Anesthesiology and Critical Care Medicine, Rennes University Hospital, Rennes, France.
  • Nguyen P; Department of Hematology and Transfusion, Lille University Hospital, Lille, France.
  • Godier A; Department of Hematology Laboratory, Reims University Hospital, Reims, France.
  • Testa S; Department of Anesthesia and Intensive Care, HEGP-AP-HP, Paris, France.
  • Levy JH; AO Istituti Ospitalieri, Cremona, Italy.
  • Albaladejo P; Duke University Hospital, Durham, NC, USA.
  • Gruel Y; Department of Anesthesiology and Critical Care, Grenoble Alpes University Hospital, La Tronche, France.
Crit Care ; 24(1): 364, 2020 06 19.
Article in English | MEDLINE | ID: covidwho-608390
ABSTRACT
COVID-19 is an infection induced by the SARS-CoV-2 coronavirus, and severe forms can lead to acute respiratory distress syndrome (ARDS) requiring intensive care unit (ICU) management. Severe forms are associated with coagulation changes, mainly characterized by an increase in D-dimer and fibrinogen levels, with a higher risk of thrombosis, particularly pulmonary embolism. The impact of obesity in severe COVID-19 has also been highlighted.In this context, standard doses of low molecular weight heparin (LMWH) may be inadequate in ICU patients, with obesity, major inflammation, and hypercoagulability. We therefore urgently developed proposals on the prevention of thromboembolism and monitoring of hemostasis in hospitalized patients with COVID-19.Four levels of thromboembolic risk were defined according to the severity of COVID-19 reflected by oxygen requirement and treatment, the body mass index, and other risk factors. Monitoring of hemostasis (including fibrinogen and D-dimer levels) every 48 h is proposed. Standard doses of LMWH (e.g., enoxaparin 4000 IU/24 h SC) are proposed in case of intermediate thrombotic risk (BMI < 30 kg/m2, no other risk factors and no ARDS). In all obese patients (high thrombotic risk), adjusted prophylaxis with intermediate doses of LMWH (e.g., enoxaparin 4000 IU/12 h SC or 6000 IU/12 h SC if weight > 120 kg), or unfractionated heparin (UFH) if renal insufficiency (200 IU/kg/24 h, IV), is proposed. The thrombotic risk was defined as very high in obese patients with ARDS and added risk factors for thromboembolism, and also in case of extracorporeal membrane oxygenation (ECMO), unexplained catheter thrombosis, dialysis filter thrombosis, or marked inflammatory syndrome and/or hypercoagulability (e.g., fibrinogen > 8 g/l and/or D-dimers > 3 µg/ml). In ICU patients, it is sometimes difficult to confirm a diagnosis of thrombosis, and curative anticoagulant treatment may also be discussed on a probabilistic basis. In all these situations, therapeutic doses of LMWH, or UFH in case of renal insufficiency with monitoring of anti-Xa activity, are proposed.In conclusion, intensification of heparin treatment should be considered in the context of COVID-19 on the basis of clinical and biological criteria of severity, especially in severely ill ventilated patients, for whom the diagnosis of pulmonary embolism cannot be easily confirmed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Thrombosis / Coronavirus Infections / Hemostasis / Hospitalization Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Crit Care Year: 2020 Document Type: Article Affiliation country: S13054-020-03000-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Thrombosis / Coronavirus Infections / Hemostasis / Hospitalization Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Crit Care Year: 2020 Document Type: Article Affiliation country: S13054-020-03000-7