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First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease.
Domingues, Renan Barros; Mendes-Correa, Maria Cássia; de Moura Leite, Fernando Brunale Vilela; Sabino, Ester Cerdeira; Salarini, Diego Zanotti; Claro, Ingra; Santos, Daniel Wagner; de Jesus, Jaqueline Goes; Ferreira, Noely Evangelista; Romano, Camila Malta; Soares, Carlos Augusto Senne.
  • Domingues RB; Senne Liquor Diagnóstico, São Paulo, SP, Brazil. renan.domingues@senneliquor.com.br.
  • Mendes-Correa MC; Virology Section (LIM-52), Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, SP, Brazil.
  • de Moura Leite FBV; Senne Liquor Diagnóstico, São Paulo, SP, Brazil.
  • Sabino EC; Instituto de Medicina Tropical de São Paulo, São Paulo, SP, Brazil.
  • Salarini DZ; Rede D´Or, Hospital São Luiz Jabaquara, São Paulo, SP, Brazil.
  • Claro I; Instituto de Medicina Tropical de São Paulo, São Paulo, SP, Brazil.
  • Santos DW; Rede D´Or, Hospital São Luiz Jabaquara, São Paulo, SP, Brazil.
  • de Jesus JG; Instituto de Medicina Tropical de São Paulo, São Paulo, SP, Brazil.
  • Ferreira NE; Instituto de Medicina Tropical de São Paulo, São Paulo, SP, Brazil.
  • Romano CM; Instituto de Medicina Tropical de São Paulo, São Paulo, SP, Brazil.
  • Soares CAS; Senne Liquor Diagnóstico, São Paulo, SP, Brazil.
J Neurol ; 267(11): 3154-3156, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-609091
Semantic information from SemMedBD (by NLM)
1. Demyelinating Diseases PROCESS_OF Patients
Subject
Demyelinating Diseases
Predicate
PROCESS_OF
Object
Patients
2. Cerebrospinal Fluid PART_OF Patients
Subject
Cerebrospinal Fluid
Predicate
PART_OF
Object
Patients
3. Encephalitis PROCESS_OF Patients
Subject
Encephalitis
Predicate
PROCESS_OF
Object
Patients
4. Cerebrospinal fluid sample PART_OF Patients
Subject
Cerebrospinal fluid sample
Predicate
PART_OF
Object
Patients
5. Neurologic Manifestations PROCESS_OF Patients
Subject
Neurologic Manifestations
Predicate
PROCESS_OF
Object
Patients
6. Symptom mild PROCESS_OF Patients
Subject
Symptom mild
Predicate
PROCESS_OF
Object
Patients
7. Virus PROCESS_OF Patients
Subject
Virus
Predicate
PROCESS_OF
Object
Patients
8. Viral Genome PART_OF 2019 novel coronavirus
Subject
Viral Genome
Predicate
PART_OF
Object
2019 novel coronavirus
9. Cerebrospinal Fluid LOCATION_OF Viral Genome
Subject
Cerebrospinal Fluid
Predicate
LOCATION_OF
Object
Viral Genome
10. Neurologic Symptoms ASSOCIATED_WITH Severe Acute Respiratory Syndrome
Subject
Neurologic Symptoms
Predicate
ASSOCIATED_WITH
Object
Severe Acute Respiratory Syndrome
11. Demyelinating Diseases PROCESS_OF Patients
Subject
Demyelinating Diseases
Predicate
PROCESS_OF
Object
Patients
12. Cerebrospinal Fluid PART_OF Patients
Subject
Cerebrospinal Fluid
Predicate
PART_OF
Object
Patients
13. Encephalitis PROCESS_OF Patients
Subject
Encephalitis
Predicate
PROCESS_OF
Object
Patients
14. Cerebrospinal fluid sample PART_OF Patients
Subject
Cerebrospinal fluid sample
Predicate
PART_OF
Object
Patients
15. Neurologic Manifestations PROCESS_OF Patients
Subject
Neurologic Manifestations
Predicate
PROCESS_OF
Object
Patients
16. Symptom mild PROCESS_OF Patients
Subject
Symptom mild
Predicate
PROCESS_OF
Object
Patients
17. Virus PROCESS_OF Patients
Subject
Virus
Predicate
PROCESS_OF
Object
Patients
18. Viral Genome PART_OF 2019 novel coronavirus
Subject
Viral Genome
Predicate
PART_OF
Object
2019 novel coronavirus
19. Cerebrospinal Fluid LOCATION_OF Viral Genome
Subject
Cerebrospinal Fluid
Predicate
LOCATION_OF
Object
Viral Genome
20. Neurologic Symptoms ASSOCIATED_WITH Severe Acute Respiratory Syndrome
Subject
Neurologic Symptoms
Predicate
ASSOCIATED_WITH
Object
Severe Acute Respiratory Syndrome
ABSTRACT
The association between coronaviruses and central nervous system (CNS) demyelinating lesions has been previously shown. However, no case has been described of an association between the novel coronavirus (SARS-COV-2) and CNS demyelinating disease so far. SARS-COV-2 was previously detected in cerebrospinal fluid (CSF) sample of a patient with encephalitis. However, the virus identity was not confirmed by deep sequencing of SARS-COV-2 detected in the CSF. Here, we report a case of a patient with mild respiratory symptoms and neurological manifestations compatible with clinically isolated syndrome. The viral genome of SARS-COV-2 was detected and sequenced in CSF with 99.74-100% similarity between the patient virus and worldwide sequences. This report suggests a possible association of SARS-COV-2 infection with neurological symptoms of demyelinating disease, even in the absence of relevant upper respiratory tract infection signs.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Demyelinating Diseases / Coronavirus Infections Type of study: Case report / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans Language: English Journal: J Neurol Year: 2020 Document Type: Article Affiliation country: S00415-020-09996-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Demyelinating Diseases / Coronavirus Infections Type of study: Case report / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans Language: English Journal: J Neurol Year: 2020 Document Type: Article Affiliation country: S00415-020-09996-w