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First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease.
Domingues, Renan Barros; Mendes-Correa, Maria Cássia; de Moura Leite, Fernando Brunale Vilela; Sabino, Ester Cerdeira; Salarini, Diego Zanotti; Claro, Ingra; Santos, Daniel Wagner; de Jesus, Jaqueline Goes; Ferreira, Noely Evangelista; Romano, Camila Malta; Soares, Carlos Augusto Senne.
  • Domingues RB; Senne Liquor Diagnóstico, São Paulo, SP, Brazil. renan.domingues@senneliquor.com.br.
  • Mendes-Correa MC; Virology Section (LIM-52), Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, SP, Brazil.
  • de Moura Leite FBV; Senne Liquor Diagnóstico, São Paulo, SP, Brazil.
  • Sabino EC; Instituto de Medicina Tropical de São Paulo, São Paulo, SP, Brazil.
  • Salarini DZ; Rede D´Or, Hospital São Luiz Jabaquara, São Paulo, SP, Brazil.
  • Claro I; Instituto de Medicina Tropical de São Paulo, São Paulo, SP, Brazil.
  • Santos DW; Rede D´Or, Hospital São Luiz Jabaquara, São Paulo, SP, Brazil.
  • de Jesus JG; Instituto de Medicina Tropical de São Paulo, São Paulo, SP, Brazil.
  • Ferreira NE; Instituto de Medicina Tropical de São Paulo, São Paulo, SP, Brazil.
  • Romano CM; Instituto de Medicina Tropical de São Paulo, São Paulo, SP, Brazil.
  • Soares CAS; Senne Liquor Diagnóstico, São Paulo, SP, Brazil.
J Neurol ; 267(11): 3154-3156, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-609091
ABSTRACT
The association between coronaviruses and central nervous system (CNS) demyelinating lesions has been previously shown. However, no case has been described of an association between the novel coronavirus (SARS-COV-2) and CNS demyelinating disease so far. SARS-COV-2 was previously detected in cerebrospinal fluid (CSF) sample of a patient with encephalitis. However, the virus identity was not confirmed by deep sequencing of SARS-COV-2 detected in the CSF. Here, we report a case of a patient with mild respiratory symptoms and neurological manifestations compatible with clinically isolated syndrome. The viral genome of SARS-COV-2 was detected and sequenced in CSF with 99.74-100% similarity between the patient virus and worldwide sequences. This report suggests a possible association of SARS-COV-2 infection with neurological symptoms of demyelinating disease, even in the absence of relevant upper respiratory tract infection signs.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Demyelinating Diseases / Coronavirus Infections Type of study: Case report / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans Language: English Journal: J Neurol Year: 2020 Document Type: Article Affiliation country: S00415-020-09996-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Demyelinating Diseases / Coronavirus Infections Type of study: Case report / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans Language: English Journal: J Neurol Year: 2020 Document Type: Article Affiliation country: S00415-020-09996-w