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Biological sex impacts COVID-19 outcomes.
Klein, Sabra L; Dhakal, Santosh; Ursin, Rebecca L; Deshpande, Sharvari; Sandberg, Kathryn; Mauvais-Jarvis, Franck.
  • Klein SL; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
  • Dhakal S; Department of Biochemistry and Molecular Biology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
  • Ursin RL; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
  • Deshpande S; Department of Biochemistry and Molecular Biology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
  • Sandberg K; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
  • Mauvais-Jarvis F; Departments of Medicine and Nephrology & Hypertension, Georgetown University, Washington, DC, United States of America.
PLoS Pathog ; 16(6): e1008570, 2020 06.
Article in English | MEDLINE | ID: covidwho-610287
ABSTRACT
The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Sex Factors / Coronavirus Infections Type of study: Experimental Studies / Observational study Limits: Humans Country/Region as subject: North America Language: English Journal: PLoS Pathog Year: 2020 Document Type: Article Affiliation country: Journal.ppat.1008570

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Sex Factors / Coronavirus Infections Type of study: Experimental Studies / Observational study Limits: Humans Country/Region as subject: North America Language: English Journal: PLoS Pathog Year: 2020 Document Type: Article Affiliation country: Journal.ppat.1008570