The Role of Genetic Sex and Mitochondria in Response to COVID-19 Infection.
Int Arch Allergy Immunol
; 181(8): 629-634, 2020.
Article
in English
| MEDLINE | ID: covidwho-610697
ABSTRACT
The difference between the female and male immune response to COVID-19 infection, and infections in general, is multifactorial. The well-known determiners of the immune response, such as X and Y chromosomes, sex hormones, and microbiota, are functionally interconnected and influence each other in shaping the organism's immunity. We focus our commentary on the interplay between the genetic sex and mitochondria and how this may affect a sex-dependent immune response in COVID-19 infection. Realizing the existence of these interactions may help in designing novel methods or fine-tuning the existing and routine therapies to fight COVID-19 and other infections.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Sex Chromosomes
/
Coronavirus Infections
/
Betacoronavirus
/
Mitochondria
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Int Arch Allergy Immunol
Journal subject:
Allergy and Immunology
Year:
2020
Document Type:
Article
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