Heart transplant recipient patient with COVID-19 treated with tocilizumab.

Mattioli, Massimo; Fustini, Elisa; Gennarini, Silvia

Mattioli, Massimo; Fustini, Elisa; Gennarini, Silvia.

Mattioli M; UOC Pronto Soccorso e Medicina d'Urgenza, Azienda Ospedaliera "Ospedali Riuniti Marche Nord", Pesaro, Italy.
Fustini E; UOC Pronto Soccorso e Medicina d'Urgenza, Azienda Ospedaliera "Ospedali Riuniti Marche Nord", Pesaro, Italy.
Gennarini S; UOC Pronto Soccorso e Medicina d'Urgenza, Azienda Ospedaliera "Ospedali Riuniti Marche Nord", Pesaro, Italy.

Transpl Infect Dis ; 22(6): e13380, 2020 Dec.

Article in English | MEDLINE | ID: covidwho-610831

ABSTRACT

ABSTRACT

A heart transplant 62-year-old patient referred for coronavirus-19 disease (COVID-19) pneumonia. At admission, he was febrile, tachypnoeic, and mild hypoxic with dry cough; during hospitalization, a diffuse morbilliform skin rash appeared. He was treated with tocilizumab with symptoms improvement, without a complete pulmonary function recovery. Skin rash, highly suggestive for COVID-19 cutaneous involvement, persisted for ten days despite tocilizumab administration.

Subject(s)

Antibodies, Monoclonal, Humanized/therapeutic use; COVID-19 Drug Treatment; Heart Transplantation; Anti-Bacterial Agents/therapeutic use; Anticoagulants/therapeutic use; COVID-19/immunology; COVID-19/physiopathology; Cardiomyopathy, Dilated/complications; Cardiomyopathy, Dilated/surgery; Cough/physiopathology; Diarrhea/physiopathology; Enoxaparin/therapeutic use; Enzyme Inhibitors/therapeutic use; Exanthema/physiopathology; Fever/physiopathology; Glucocorticoids/therapeutic use; Humans; Hydroxychloroquine/therapeutic use; Hypoxia/physiopathology; Immunocompromised Host/immunology; Immunosuppressive Agents/therapeutic use; Male; Methylprednisolone/therapeutic use; Middle Aged; Nausea/physiopathology; Piperacillin, Tazobactam Drug Combination/therapeutic use; Pulmonary Disease, Chronic Obstructive/complications; Renal Insufficiency, Chronic/complications; SARS-CoV-2; Tachypnea/physiopathology; Treatment Outcome

Keywords

COVID-19; heart transplant; pneumonia; tocilizumab

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Heart Transplantation / Antibodies, Monoclonal, Humanized / COVID-19 Drug Treatment Type of study: Case report / Prognostic study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: Transpl Infect Dis Journal subject: Transplantation Year: 2020 Document Type: Article Affiliation country: Tid.13380

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