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A Comparison Between Chinese Children Infected with Coronavirus Disease-2019 and with Severe Acute Respiratory Syndrome 2003.
Xiong, Xiaoli; Chua, Gilbert T; Chi, Shuiqing; Kwan, Mike Yat Wah; Sang Wong, Wilfred Hing; Zhou, Aifen; Shek, Chi Chiu; Tung, Keith T S; Qin, Huan; Wong, Rosa S; Li, Xue; Chen, Peng; Li, Shuai; Chui, Celine S; Tso, Winnie W Y; Ho, Marco H K; Wong, Ian C K; Chan, Godfrey C F; Lau, Yu Lung; Wong, Kenneth K Y; Chung, Patrick H Y; Li, Hui; Tam, Paul K H; Tang, Shao-Tao; Ip, Patrick.
  • Xiong X; Department of Integrated Chinese and Western Medicine, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Chua GT; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Chi S; Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Kwan MYW; Department of Pediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong SAR, China.
  • Sang Wong WH; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Zhou A; Department of Maternal Healthcare, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Shek CC; Department of Pediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong SAR, China.
  • Tung KTS; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Qin H; Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan.
  • Wong RS; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Li X; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China; Center for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China.
  • Chen P; Department of Respiratory Medicine, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Li S; Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Chui CS; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China; Center for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China.
  • Tso WWY; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Ho MHK; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Wong ICK; Center for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China; Research Department of Practice and Policy, UCL School of Pharmacy, University College, London, UK.
  • Chan GCF; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Lau YL; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Wong KKY; Division of Pediatric Surgery, Department of Surgery, The University of Hong Kong, Hong Kong SAR, China.
  • Chung PHY; Division of Pediatric Surgery, Department of Surgery, The University of Hong Kong, Hong Kong SAR, China.
  • Li H; Department of Hematology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Tam PKH; Division of Pediatric Surgery, Department of Surgery, The University of Hong Kong, Hong Kong SAR, China; Dr. Li Dak Sum Research Center, The University of Hong Kong-Karolinska Institute Collaboration in Regenerative Medicine, The University of Hong Kong, China.
  • Tang ST; Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Ip P; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China. Electronic address: patricip@hku.hk.
J Pediatr ; 224: 30-36, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-662046
ABSTRACT

OBJECTIVES:

To compare the clinical and laboratory features of severe acute respiratory syndrome 2003 (SARS) and coronavirus disease 2019 (COVID-19) in 2 Chinese pediatric cohorts, given that the causative pathogens and are biologically similar. STUDY

DESIGN:

This is a cross-sectional study reviewing pediatric patients with SARS (n = 43) and COVID-19 (n = 244) who were admitted to the Princess Margaret Hospital in Hong Kong and Wuhan Children's Hospital in Wuhan, respectively. Demographics, hospital length of stay, and clinical and laboratory features were compared.

RESULTS:

Overall, 97.7% of patients with SARS and 85.2% of patients with COVID-19 had epidemiologic associations with known cases. Significantly more patients with SARS developed fever, chills, myalgia, malaise, coryza, sore throat, sputum production, nausea, headache, and dizziness than patients with COVID-19. No patients with SARS were asymptomatic at the time of admission, whereas 29.1% and 20.9% of patients with COVID-19 were asymptomatic on admission and throughout their hospital stay, respectively. More patients with SARS required oxygen supplementation than patients with COVID-19 (18.6 vs 4.7%; P = .004). Only 1.6% of patients with COVID-19 and 2.3% of patients with SARS required mechanical ventilation. Leukopenia (37.2% vs 18.6%; P = .008), lymphopenia (95.4% vs 32.6%; P < .01), and thrombocytopenia (41.9% vs 3.8%; P < .001) were significantly more common in patients with SARS than in patients with COVID-19. The duration between positive and negative nasopharyngeal aspirate and the length in hospital stay were similar in patients with COVID-19, regardless of whether they were asymptomatic or symptomatic, suggesting a similar duration of viral shedding.

CONCLUSIONS:

Children with COVID-19 were less symptomatic and had more favorable hematologic findings than children with SARS.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Severe Acute Respiratory Syndrome Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Asia Language: English Journal: J Pediatr Year: 2020 Document Type: Article Affiliation country: J.jpeds.2020.06.041

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Severe Acute Respiratory Syndrome Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Asia Language: English Journal: J Pediatr Year: 2020 Document Type: Article Affiliation country: J.jpeds.2020.06.041