Your browser doesn't support javascript.
A Primary Mediastinal Large B-Cell Lymphoma Patient With COVID-19 Infection After Intensive Immunochemotherapy: A Case Report.
Li, Qiuhui; Zhu, Fang; Xiao, Yin; Liu, Tao; Liu, Xinxiu; Wu, Gang; Zhang, Liling.
  • Li Q; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhu F; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xiao Y; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Liu T; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Liu X; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wu G; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang L; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Oncol ; 10: 924, 2020.
Article in English | MEDLINE | ID: covidwho-611825
Semantic information from SemMedBD (by NLM)
1. Mediastinal (Thymic) Large B-Cell Lymphoma PROCESS_OF Patients
Subject
Mediastinal (Thymic) Large B-Cell Lymphoma
Predicate
PROCESS_OF
Object
Patients
2. Lymphoma PROCESS_OF Patients
Subject
Lymphoma
Predicate
PROCESS_OF
Object
Patients
3. Febrile Neutropenia PROCESS_OF Patients
Subject
Febrile Neutropenia
Predicate
PROCESS_OF
Object
Patients
4. Chest CT AFFECTS Patients
Subject
Chest CT
Predicate
AFFECTS
Object
Patients
5. hydrochloride TREATS COVID-19
Subject
hydrochloride
Predicate
TREATS
Object
COVID-19
6. Immunotherapy for cancer TREATS Lymphoma
Subject
Immunotherapy for cancer
Predicate
TREATS
Object
Lymphoma
7. Immunotherapy for cancer TREATS Patients
Subject
Immunotherapy for cancer
Predicate
TREATS
Object
Patients
8. Visual Accommodation PROCESS_OF Patients
Subject
Visual Accommodation
Predicate
PROCESS_OF
Object
Patients
9. Mediastinal (Thymic) Large B-Cell Lymphoma PROCESS_OF Patients
Subject
Mediastinal (Thymic) Large B-Cell Lymphoma
Predicate
PROCESS_OF
Object
Patients
10. Lymphoma PROCESS_OF Patients
Subject
Lymphoma
Predicate
PROCESS_OF
Object
Patients
11. Febrile Neutropenia PROCESS_OF Patients
Subject
Febrile Neutropenia
Predicate
PROCESS_OF
Object
Patients
12. Chest CT AFFECTS Patients
Subject
Chest CT
Predicate
AFFECTS
Object
Patients
13. hydrochloride TREATS COVID-19
Subject
hydrochloride
Predicate
TREATS
Object
COVID-19
14. Immunotherapy for cancer TREATS Lymphoma
Subject
Immunotherapy for cancer
Predicate
TREATS
Object
Lymphoma
15. Immunotherapy for cancer TREATS Patients
Subject
Immunotherapy for cancer
Predicate
TREATS
Object
Patients
16. Visual Accommodation PROCESS_OF Patients
Subject
Visual Accommodation
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

Background:

The outbreak of coronavirus disease 2019 (COVID-19) had become a global public health event. Lymphoma patients need to be distinguished from the general population because of their deficient immune status and intensive anti-tumor treatment. The impacts of cancer subtypes and treatment on COVID-19 infection are unclear. Case Presentation We here report the case of a primary mediastinal large B-cell lymphoma patient who was infected with COVID-19 after intensive immunochemotherapy (DA-EPOCH-R). The patient developed a neutropenic fever during chemotherapy, and fever was persistent, although antibiotics were used. Initial chest CT was negative, and the patient received a throat swab test since the second CT showed evidence of pneumonia. With treatment with Arbidol Hydrochloride and LianHuaQingWen capsule, his COVID-19 was cured.

Conclusions:

To the best of our knowledge, this is the first report focusing on COVID-19 infection in a lymphoma patient undergoing intensive immunochemotherapy. For those patients being treated with immunochemotherapy in epidemic areas, a reduced dose intensity of intensive chemotherapy should be considered, and the effect of immunotherapies such as rituximab on COVID-19 infection should be considered. The impacts of anti-cancer treatment on COVID-19 infection need to be explored further.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report Language: English Journal: Front Oncol Year: 2020 Document Type: Article Affiliation country: Fonc.2020.00924

Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report Language: English Journal: Front Oncol Year: 2020 Document Type: Article Affiliation country: Fonc.2020.00924