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Imiquimod - A toll like receptor 7 agonist - Is an ideal option for management of COVID 19.
Angelopoulou, Athina; Alexandris, Nikos; Konstantinou, Evangelia; Mesiakaris, Konstantinos; Zanidis, Charilaos; Farsalinos, Konstantinos; Poulas, Konstantinos.
  • Angelopoulou A; Laboratory of Molecular Biology and Immunology, Department of Pharmacy, University of Patras, 26500, Greece.
  • Alexandris N; Laboratory of Molecular Biology and Immunology, Department of Pharmacy, University of Patras, 26500, Greece.
  • Konstantinou E; Laboratory of Molecular Biology and Immunology, Department of Pharmacy, University of Patras, 26500, Greece.
  • Mesiakaris K; Laboratory of Molecular Biology and Immunology, Department of Pharmacy, University of Patras, 26500, Greece.
  • Zanidis C; Laboratory of Molecular Biology and Immunology, Department of Pharmacy, University of Patras, 26500, Greece.
  • Farsalinos K; Laboratory of Molecular Biology and Immunology, Department of Pharmacy, University of Patras, 26500, Greece.
  • Poulas K; Laboratory of Molecular Biology and Immunology, Department of Pharmacy, University of Patras, 26500, Greece. Electronic address: kpoulas@upatras.gr.
Environ Res ; 188: 109858, 2020 09.
Article in English | MEDLINE | ID: covidwho-611836
ABSTRACT
According to numerous recent publications, the COVID-19 patients have lymphopenia, higher infection-related biomarkers and several elevated inflammatory cytokines (i.e. tumor necrosis factor (TNF)-α, interleukin IL-2R and IL-6). The total number of B cells, T cells and NK cells are significantly decreased. RNA viruses, SARS-CoV-2 included, hit the innate immune system in order to cause infection, through TLRs 3, 7 and 8. Imiquimod is an immune-stimulator that activates TLR 7 and can be used to enhance the innate and adaptive immunity. Preclinical and clinical trials are proposed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Toll-Like Receptor 7 / Imiquimod Type of study: Prognostic study Topics: Variants Limits: Humans Language: English Journal: Environ Res Year: 2020 Document Type: Article Affiliation country: J.envres.2020.109858

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Toll-Like Receptor 7 / Imiquimod Type of study: Prognostic study Topics: Variants Limits: Humans Language: English Journal: Environ Res Year: 2020 Document Type: Article Affiliation country: J.envres.2020.109858