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[Screening of Mothers in a COVID-19 Low-Prevalence Region: Determination of SARS-CoV-2 Antibodies in 401 Mothers from Rostock by ELISA and Confirmation by Immunofluorescence]. / Mütter-Screening in einem COVID-19-Niedrig-Pandemiegebiet: Bestimmung SARS-CoV-2-spezifischer Antikörper bei 401 Rostocker Müttern mittels ELISA und Immunfluoreszenz-Bestätigungstest.
Reisinger, Emil C; von Possel, Ronald; Warnke, Philipp; Geerdes-Fenge, Hilte F; Hemmer, Christoph J; Pfefferle, Susanne; Löbermann, Micha; Littmann, Martina; Emmerich, Petra.
  • Reisinger EC; Abteilung für Tropenmedizin und Infektionskrankheiten, Klinik für Innere Medizin, Universitätsmedizin Rostock.
  • von Possel R; Bernhard-Nocht-Institut für Tropenmedizin, Abteilung Virologie, Hamburg.
  • Warnke P; Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universitätsmedizin Rostock.
  • Geerdes-Fenge HF; Abteilung für Tropenmedizin und Infektionskrankheiten, Klinik für Innere Medizin, Universitätsmedizin Rostock.
  • Hemmer CJ; Abteilung für Tropenmedizin und Infektionskrankheiten, Klinik für Innere Medizin, Universitätsmedizin Rostock.
  • Pfefferle S; Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universitätsklinikum Eppendorf, Hamburg.
  • Löbermann M; Abteilung für Tropenmedizin und Infektionskrankheiten, Klinik für Innere Medizin, Universitätsmedizin Rostock.
  • Littmann M; Landesamt für Gesundheit und Soziales, Mecklenburg-Vorpommern.
  • Emmerich P; Abteilung für Tropenmedizin und Infektionskrankheiten, Klinik für Innere Medizin, Universitätsmedizin Rostock.
Dtsch Med Wochenschr ; 145(17): e96-e100, 2020 08.
Article in German | MEDLINE | ID: covidwho-612422
Semantic information from SemMedBD (by NLM)
1. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
2. Fluorescent Antibody Technique METHOD_OF Screening procedure
Subject
Fluorescent Antibody Technique
Predicate
METHOD_OF
Object
Screening procedure
3. Enzyme-Linked Immunosorbent Assay METHOD_OF Screening procedure
Subject
Enzyme-Linked Immunosorbent Assay
Predicate
METHOD_OF
Object
Screening procedure
4. Antibodies TREATS Mother (person)
Subject
Antibodies
Predicate
TREATS
Object
Mother (person)
5. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
6. Borg Category-Ratio 10 Perceived Exertion Score 5 PROCESS_OF Adult
Subject
Borg Category-Ratio 10 Perceived Exertion Score 5
Predicate
PROCESS_OF
Object
Adult
7. Serum LOCATION_OF Antibodies
Subject
Serum
Predicate
LOCATION_OF
Object
Antibodies
8. Laboratory Procedures USES Enzyme-Linked Immunosorbent Assay
Subject
Laboratory Procedures
Predicate
USES
Object
Enzyme-Linked Immunosorbent Assay
9. Laboratory Procedures USES Indirect Immunofluorescence
Subject
Laboratory Procedures
Predicate
USES
Object
Indirect Immunofluorescence
10. 2019 novel coronavirus PROCESS_OF Mother (person)
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Mother (person)
11. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
12. Fluorescent Antibody Technique METHOD_OF Screening procedure
Subject
Fluorescent Antibody Technique
Predicate
METHOD_OF
Object
Screening procedure
13. Enzyme-Linked Immunosorbent Assay METHOD_OF Screening procedure
Subject
Enzyme-Linked Immunosorbent Assay
Predicate
METHOD_OF
Object
Screening procedure
14. Antibodies TREATS Mother (person)
Subject
Antibodies
Predicate
TREATS
Object
Mother (person)
15. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
16. Borg Category-Ratio 10 Perceived Exertion Score 5 PROCESS_OF Adult
Subject
Borg Category-Ratio 10 Perceived Exertion Score 5
Predicate
PROCESS_OF
Object
Adult
17. Serum LOCATION_OF Antibodies
Subject
Serum
Predicate
LOCATION_OF
Object
Antibodies
18. Laboratory Procedures USES Enzyme-Linked Immunosorbent Assay
Subject
Laboratory Procedures
Predicate
USES
Object
Enzyme-Linked Immunosorbent Assay
19. Laboratory Procedures USES Indirect Immunofluorescence
Subject
Laboratory Procedures
Predicate
USES
Object
Indirect Immunofluorescence
20. 2019 novel coronavirus PROCESS_OF Mother (person)
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Mother (person)
ABSTRACT

BACKGROUND:

In children, the infection with SARS-CoV-2, the cause of COVID-19, tends to be clinically inapparent more often or less severe than in adults. The spread of this infection from children poses a danger to vulnerable adults. Therefore, child care institutions and schools currently are widely closed.

METHODS:

Since the status of infection tends to be congruent in mothers and their children, we tested 401 mothers of children between 1 and 10 years in the city of Rostock (State of Mecklenburg-Westpomerania, northeast of Germany), for the presence of RNA of SARS-CoV-2 in throat swabs, and of antibodies against SARS-CoV-2 in serum.

RESULTS:

In none of the mothers tested, RNA of this virus was detected in the throat swab. In the ELISA test, IgG antibodies were positive in one serum sample, IgA antibodies were positive in 11, and borderline in 3 serum samples. All 401 sera were negative in the indirect immunofluorescence test (IIFT) with FITC-labeled IgG, IgA, und IgM antibodies.

CONCLUSION:

At the time of this study, neither SARS-CoV-2 RNA, nor specific antibodies against SARS-CoV-2 were detectable in the mothers tested in Rostock.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Antibodies, Viral Type of study: Diagnostic study / Prevalence study / Prognostic study / Risk factors / Screening study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Europa Language: German Journal: Dtsch Med Wochenschr Year: 2020 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Antibodies, Viral Type of study: Diagnostic study / Prevalence study / Prognostic study / Risk factors / Screening study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Europa Language: German Journal: Dtsch Med Wochenschr Year: 2020 Document Type: Article