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Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis.
Song, Jin-Wen; Lam, Sin Man; Fan, Xing; Cao, Wen-Jing; Wang, Si-Yu; Tian, He; Chua, Gek Huey; Zhang, Chao; Meng, Fan-Ping; Xu, Zhe; Fu, Jun-Liang; Huang, Lei; Xia, Peng; Yang, Tao; Zhang, Shaohua; Li, Bowen; Jiang, Tian-Jun; Wang, Raoxu; Wang, Zehua; Shi, Ming; Zhang, Ji-Yuan; Wang, Fu-Sheng; Shui, Guanghou.
  • Song JW; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China.
  • Lam SM; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; LipidALL Technologies Company Limited, Changzhou, 213022 Jiangsu Province, China.
  • Fan X; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China.
  • Cao WJ; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China; Department of Clinical Medicine, Bengbu Medical College, Bengbu 233000, China.
  • Wang SY; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China.
  • Tian H; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
  • Chua GH; LipidALL Technologies Company Limited, Changzhou, 213022 Jiangsu Province, China.
  • Zhang C; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China.
  • Meng FP; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China.
  • Xu Z; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China.
  • Fu JL; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China.
  • Huang L; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China.
  • Xia P; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China.
  • Yang T; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China.
  • Zhang S; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
  • Li B; LipidALL Technologies Company Limited, Changzhou, 213022 Jiangsu Province, China.
  • Jiang TJ; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China.
  • Wang R; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
  • Wang Z; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
  • Shi M; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China.
  • Zhang JY; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China. Electronic address: uniquezjy@163.com.
  • Wang FS; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China. Electronic address: fswang302@163.com.
  • Shui G; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: ghshui@genetics.ac.cn.
Cell Metab ; 32(2): 188-202.e5, 2020 08 04.
Article in English | MEDLINE | ID: covidwho-612608
Semantic information from SemMedBD (by NLM)
1. Plasma LOCATION_OF Lipidome
Subject
Plasma
Predicate
LOCATION_OF
Object
Lipidome
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Sphingomyelins INHIBITS Diglycerides
Subject
Sphingomyelins
Predicate
INHIBITS
Object
Diglycerides
4. Exosomes PART_OF Patients
Subject
Exosomes
Predicate
PART_OF
Object
Patients
5. Pathologic Processes COEXISTS_WITH COVID-19
Subject
Pathologic Processes
Predicate
COEXISTS_WITH
Object
COVID-19
6. Plasma LOCATION_OF Lipidome
Subject
Plasma
Predicate
LOCATION_OF
Object
Lipidome
7. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
8. Sphingomyelins INHIBITS Diglycerides
Subject
Sphingomyelins
Predicate
INHIBITS
Object
Diglycerides
9. Exosomes PART_OF Patients
Subject
Exosomes
Predicate
PART_OF
Object
Patients
10. Pathologic Processes COEXISTS_WITH COVID-19
Subject
Pathologic Processes
Predicate
COEXISTS_WITH
Object
COVID-19
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and untargeted tandem mass spectrometry to analyze the plasma lipidome and metabolome in mild, moderate, and severe COVID-19 patients and healthy controls. A panel of 10 plasma metabolites effectively distinguished COVID-19 patients from healthy controls (AUC = 0.975). Plasma lipidome of COVID-19 resembled that of monosialodihexosyl ganglioside (GM3)-enriched exosomes, with enhanced levels of sphingomyelins (SMs) and GM3s, and reduced diacylglycerols (DAGs). Systems evaluation of metabolic dysregulation in COVID-19 was performed using multiscale embedded differential correlation network analyses. Using exosomes isolated from the same cohort, we demonstrated that exosomes of COVID-19 patients with elevating disease severity were increasingly enriched in GM3s. Our work suggests that GM3-enriched exosomes may partake in pathological processes related to COVID-19 pathogenesis and presents the largest repository on the plasma lipidome and metabolome distinct to COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Exosomes / G(M3) Ganglioside / Gangliosides Type of study: Etiology study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Cell Metab Journal subject: Metabolism Year: 2020 Document Type: Article Affiliation country: J.cmet.2020.06.016

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Exosomes / G(M3) Ganglioside / Gangliosides Type of study: Etiology study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Cell Metab Journal subject: Metabolism Year: 2020 Document Type: Article Affiliation country: J.cmet.2020.06.016