Your browser doesn't support javascript.
Unique fibrinogen-binding motifs in the nucleocapsid phosphoprotein of SARS CoV-2: Potential implications in host-pathogen interactions.
Sangith, Nikhil.
  • Sangith N; Xact Diagnotek Private Limited, Anna University Bioincubator, Taramani, Chennai 600113, India. Electronic address: nikhil.sangith@gmail.com.
Med Hypotheses ; 144: 110030, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-612684
Semantic information from SemMedBD (by NLM)
1. Phosphoproteins PART_OF Nucleocapsid
Subject
Phosphoproteins
Predicate
PART_OF
Object
Nucleocapsid
2. Phosphoproteins PART_OF 2019 novel coronavirus
Subject
Phosphoproteins
Predicate
PART_OF
Object
2019 novel coronavirus
3. Phosphoproteins INTERACTS_WITH fibrinogen
Subject
Phosphoproteins
Predicate
INTERACTS_WITH
Object
fibrinogen
4. Phosphoproteins INTERACTS_WITH prothrombin
Subject
Phosphoproteins
Predicate
INTERACTS_WITH
Object
prothrombin
5. Binding Proteins PART_OF von Willebrand factor
Subject
Binding Proteins
Predicate
PART_OF
Object
von Willebrand factor
6. Extracellular LOCATION_OF fibrinogen binding
Subject
Extracellular
Predicate
LOCATION_OF
Object
fibrinogen binding
7. secretory protein COEXISTS_WITH Coagulase
Subject
secretory protein
Predicate
COEXISTS_WITH
Object
Coagulase
8. Measles Virus Nucleoprotein PART_OF Virus
Subject
Measles Virus Nucleoprotein
Predicate
PART_OF
Object
Virus
9. Measles Virus Nucleoprotein AFFECTS Anabolism
Subject
Measles Virus Nucleoprotein
Predicate
AFFECTS
Object
Anabolism
10. Phosphoproteins PART_OF Nucleocapsid
Subject
Phosphoproteins
Predicate
PART_OF
Object
Nucleocapsid
11. Phosphoproteins PART_OF 2019 novel coronavirus
Subject
Phosphoproteins
Predicate
PART_OF
Object
2019 novel coronavirus
12. Phosphoproteins INTERACTS_WITH fibrinogen
Subject
Phosphoproteins
Predicate
INTERACTS_WITH
Object
fibrinogen
13. Phosphoproteins INTERACTS_WITH prothrombin
Subject
Phosphoproteins
Predicate
INTERACTS_WITH
Object
prothrombin
14. Binding Proteins PART_OF von Willebrand factor
Subject
Binding Proteins
Predicate
PART_OF
Object
von Willebrand factor
15. Extracellular LOCATION_OF fibrinogen binding
Subject
Extracellular
Predicate
LOCATION_OF
Object
fibrinogen binding
16. secretory protein COEXISTS_WITH Coagulase
Subject
secretory protein
Predicate
COEXISTS_WITH
Object
Coagulase
17. Measles Virus Nucleoprotein PART_OF Virus
Subject
Measles Virus Nucleoprotein
Predicate
PART_OF
Object
Virus
18. Measles Virus Nucleoprotein AFFECTS Anabolism
Subject
Measles Virus Nucleoprotein
Predicate
AFFECTS
Object
Anabolism
ABSTRACT
Novel Coronavirus (SARS CoV-2), the etiological agent for the highly contagious Corona virus disease-2019 (COVID-19) pandemic has threatened global health and economy infecting around 5.8 million people and causing over 359,200 deaths (as of 28th May 2020, https//www.worldometers.info/coronavirus/). The clinical manifestations of infected patients generally range from asymptomatic or mild to severe illness, or even death. The ability of the virus to evade the host immune response have been major reasons for high morbidity and mortality. One of the important clinical observations under conditions of critical illness show increased risk of developing disseminated intravascular coagulation. Molecular mechanisms of how SARS CoV-2 induces such conditions still remain unclear. This report describes the presence of two unique motifs in the SARS CoV-2 nucleocapsid phosphoprotein (N-protein) that can potentially interact with fibrinogen and possibly prothrombin. This is based on an established function of secretory proteins in Staphylococcus aureus (S. aureus)-coagulase, Efb (Extracellular fibrinogen binding) and vWBP (von Willebrand factor Binding Protein), which are known to regulate the blood clotting cascade and the functions of host immune response. It is hypothesized that having protein interaction motifs that are homologous to these S. aureus proteins, the N-protein of this virus can mimic their functions, which may in turn play a crucial role in formation of blood clots in the host and help the virus evade host immune response. However, this hypothesis needs to be tested in vitro. Considering the overwhelming increase in the incidence of SARS CoV-2 infection globally, this information may be useful for further investigation and could help in deducing new therapeutic strategies to combat advanced stages of this disease.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Bacterial Proteins / Fibrinogen / Host-Pathogen Interactions / Coronavirus Nucleocapsid Proteins / SARS-CoV-2 / COVID-19 Subject: Bacterial Proteins / Fibrinogen / Host-Pathogen Interactions / Coronavirus Nucleocapsid Proteins / SARS-CoV-2 / COVID-19 Language: English Journal: Med Hypotheses Clinical aspect: Etiology Year: 2020

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Bacterial Proteins / Fibrinogen / Host-Pathogen Interactions / Coronavirus Nucleocapsid Proteins / SARS-CoV-2 / COVID-19 Subject: Bacterial Proteins / Fibrinogen / Host-Pathogen Interactions / Coronavirus Nucleocapsid Proteins / SARS-CoV-2 / COVID-19 Language: English Journal: Med Hypotheses Clinical aspect: Etiology Year: 2020
...