Targeting innate immunity by blocking CD14: Novel approach to control inflammation and organ dysfunction in COVID-19 illness.

Martin, Thomas R; Wurfel, Mark M; Zanoni, Ivan; Ulevitch, Richard

Martin, Thomas R; Wurfel, Mark M; Zanoni, Ivan; Ulevitch, Richard.

Martin TR; Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington School of Medicine, Seattle, WA, United States. Electronic address: trmartin@uw.edu.
Wurfel MM; Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington School of Medicine, Seattle, WA, United States.
Zanoni I; Division of Immunology, Division of Gastroenterology, Boston Children's Hospital, Harvard Medical School, Boston, MA,United States.
Ulevitch R; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA, United States.

EBioMedicine ; 57: 102836, 2020 Jul.

Article in English | MEDLINE | ID: covidwho-612734

Subject(s)

Betacoronavirus/immunology; Coronavirus Infections/drug therapy; Cytokine Release Syndrome/prevention & control; Cytokines/metabolism; Lipopolysaccharide Receptors/antagonists & inhibitors; Pneumonia, Viral/drug therapy; Angiotensin-Converting Enzyme 2; COVID-19; Coronavirus Infections/immunology; Coronavirus Infections/pathology; Cytokine Release Syndrome/pathology; Humans; Immunity, Innate/immunology; Inflammation/prevention & control; Pandemics; Peptidyl-Dipeptidase A/metabolism; Pneumonia, Viral/immunology; Pneumonia, Viral/pathology; SARS-CoV-2; Serine Endopeptidases/metabolism

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cytokines / Coronavirus Infections / Lipopolysaccharide Receptors / Betacoronavirus / Cytokine Release Syndrome Limits: Humans Language: English Journal: EBioMedicine Year: 2020 Document Type: Article

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