A case of possible atypical demyelinating event of the central nervous system following COVID-19.
Mult Scler Relat Disord
; 44: 102324, 2020 Sep.
Article
in English
| MEDLINE | ID: covidwho-613379
ABSTRACT
After the novel coronavirus disease outbreak first began in Wuhan, China, in December 2019, the viral epidemic has quickly spread across the world, and it is now a major public health concern. Here we present a 21-year-old male with encephalomyelitis following intermittent vomiting and malaise for 4 days. He reported upper respiratory signs and symptoms 2 weeks before this presentation. Two cerebrospinal fluid (CSF) analyses were notable for mononuclear pleocytosis, elevated protein (more than 100 mg/dl), and hypoglycorrhachia. Brain Magnetic Resonance Imaging (MRI) showed bilateral posterior internal capsule lesions extending to the ventral portion of the pons and a marbled splenium hyperintensity pattern. Cervical and thoracic MRI showed longitudinally extensive transverse myelitis (LETM), none of which were enhanced with gadolinium. Both the AQP4 and MOG antibodies were negative. Spiral chest computed tomography (CT) scan confirmed to COVID-19 as did the high IgG level against coronavirus, but the oropharyngeal swabs were negative. Neurological manifestations of COVID-19 have not been adequately studied. Some COVID-19 patients, especially those suffering from a severe disease, are highly likely to have central nervous system (CNS) manifestations. Our case is a post-COVID-19 demyelinating event in the CNS.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Demyelinating Diseases
/
Encephalomyelitis
/
COVID-19
Type of study:
Prognostic study
Topics:
Long Covid
Limits:
Adult
/
Humans
/
Male
/
Young adult
Language:
English
Journal:
Mult Scler Relat Disord
Year:
2020
Document Type:
Article
Affiliation country:
J.msard.2020.102324
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