Autophagy/virophagy: a "disposal strategy" to combat COVID-19.
Autophagy
; 16(12): 2271-2272, 2020 12.
Article
in English
| MEDLINE | ID: covidwho-613427
ABSTRACT
Given the devastating consequences of the current COVID-19 pandemic and its impact on all of us, the question arises as to whether manipulating the cellular degradation (recycling, waste disposal) mechanism known as macroautophagy/autophagy (in particular, the selective degradation of virus particles, termed virophagy) might be a beneficial approach to fight the novel coronavirus, SARS-CoV-2. Knowing that "autophagy can reprocess everything", it seems almost inevitable that, sooner rather than later, a further hypothesis-driven work will detail the role of virophagy as a fundamental "disposal strategy" against COVID-19, yielding most needed therapeutic interventions. Abbreviations ATG, autophagy-related; CoV/CoVs coronavirus/coronaviruses; COVID-19, coronavirus disease 2019; MERS-CoV, Middle East respiratory syndrome coronavirus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Phagocytosis
/
Autophagy
/
SARS-CoV-2
/
COVID-19
/
Immunity, Cellular
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Autophagy
Year:
2020
Document Type:
Article
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