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Autophagy/virophagy: a "disposal strategy" to combat COVID-19.
Mijaljica, Dalibor; Klionsky, Daniel J.
  • Mijaljica D; Independent Scholar.
  • Klionsky DJ; Department of Molecular, Cellular, and Developmental Biology, and the Life Sciences Institute, University of Michigan , Ann Arbor, MI, USA.
Autophagy ; 16(12): 2271-2272, 2020 12.
Article in English | MEDLINE | ID: covidwho-613427
ABSTRACT
Given the devastating consequences of the current COVID-19 pandemic and its impact on all of us, the question arises as to whether manipulating the cellular degradation (recycling, waste disposal) mechanism known as macroautophagy/autophagy (in particular, the selective degradation of virus particles, termed virophagy) might be a beneficial approach to fight the novel coronavirus, SARS-CoV-2. Knowing that "autophagy can reprocess everything", it seems almost inevitable that, sooner rather than later, a further hypothesis-driven work will detail the role of virophagy as a fundamental "disposal strategy" against COVID-19, yielding most needed therapeutic interventions. Abbreviations ATG, autophagy-related; CoV/CoVs coronavirus/coronaviruses; COVID-19, coronavirus disease 2019; MERS-CoV, Middle East respiratory syndrome coronavirus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Phagocytosis / Autophagy / SARS-CoV-2 / COVID-19 / Immunity, Cellular Type of study: Observational study Limits: Humans Language: English Journal: Autophagy Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Phagocytosis / Autophagy / SARS-CoV-2 / COVID-19 / Immunity, Cellular Type of study: Observational study Limits: Humans Language: English Journal: Autophagy Year: 2020 Document Type: Article