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Extracorporeal blood purification treatment options for COVID-19: The role of immunoadsorption.
Yigenoglu, Tugçe Nur; Ulas, Turgay; Dal, Mehmet Sinan; Korkmaz, Serdal; Erkurt, Mehmet Ali; Altuntas, Fevzi.
  • Yigenoglu TN; University of Health Sciences, Ankara Oncology Training and Research Hospital, Department of Hematology & Apheresis Unit, Ankara, Turkey.
  • Ulas T; Near East University, School of Medicine, Department of Internal Medicine, Division of Hematology, Nicosia, Cyprus.
  • Dal MS; University of Health Sciences, Ankara Oncology Training and Research Hospital, Department of Hematology & Apheresis Unit, Ankara, Turkey.
  • Korkmaz S; University of Health Sciences, Kayseri Training and Research Hospital, Department of Hematology & Apheresis Unit, Kayseri, Turkey.
  • Erkurt MA; Inönü University, School of Medicine, Department of Internal Medicine, Division of Hematology & Apheresis Unit, Malatya, Turkey.
  • Altuntas F; University of Health Sciences, Ankara Oncology Training and Research Hospital, Department of Hematology & Apheresis Unit, Ankara, Turkey; Ankara Yildirim Beyazit University, School of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey. Electronic address: faltuntas
Transfus Apher Sci ; 59(4): 102855, 2020 Aug.
Article in English | MEDLINE | ID: covidwho-613576
Semantic information from SemMedBD (by NLM)
1. Blood Vessel LOCATION_OF Extravasation
Subject
Blood Vessel
Predicate
LOCATION_OF
Object
Extravasation
2. Alveolar LOCATION_OF Edema
Subject
Alveolar
Predicate
LOCATION_OF
Object
Edema
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
4. Respiratory Distress Syndrom OCCURS_IN C0030705
Subject
Respiratory Distress Syndrom
Predicate
OCCURS_IN
Object
C0030705
5. Hypoxia OCCURS_IN Patients
Subject
Hypoxia
Predicate
OCCURS_IN
Object
Patients
6. Vaccines TREATS COVID-19
Subject
Vaccines
Predicate
TREATS
Object
COVID-19
7. Therapeutic procedure TREATS COVID-19
Subject
Therapeutic procedure
Predicate
TREATS
Object
COVID-19
8. Poor outcome COEXISTS_WITH Systemic Inflammatory Response Syndrome
Subject
Poor outcome
Predicate
COEXISTS_WITH
Object
Systemic Inflammatory Response Syndrome
9. Storm NOS PROCESS_OF Patients
Subject
Storm NOS
Predicate
PROCESS_OF
Object
Patients
10. Adjuvant Therapy TREATS Septicemia
Subject
Adjuvant Therapy
Predicate
TREATS
Object
Septicemia
11. cytokine AFFECTS Immune response
Subject
cytokine
Predicate
AFFECTS
Object
Immune response
12. CD69 protei AFFECTS C0301872
Subject
CD69 protei
Predicate
AFFECTS
Object
C0301872
13. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
14. Storm NOS CAUSES Complication
Subject
Storm NOS
Predicate
CAUSES
Object
Complication
15. adjunctive treatment TREATS Complication
Subject
adjunctive treatment
Predicate
TREATS
Object
Complication
16. Blood Vessel LOCATION_OF Extravasation
Subject
Blood Vessel
Predicate
LOCATION_OF
Object
Extravasation
17. Alveolar LOCATION_OF Edema
Subject
Alveolar
Predicate
LOCATION_OF
Object
Edema
18. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
19. Respiratory Distress Syndrome, Adult OCCURS_IN Patients
Subject
Respiratory Distress Syndrome, Adult
Predicate
OCCURS_IN
Object
Patients
20. Hypoxia OCCURS_IN Patients
Subject
Hypoxia
Predicate
OCCURS_IN
Object
Patients
21. Vaccines TREATS COVID-19
Subject
Vaccines
Predicate
TREATS
Object
COVID-19
22. Therapeutic procedure TREATS COVID-19
Subject
Therapeutic procedure
Predicate
TREATS
Object
COVID-19
23. Poor outcome COEXISTS_WITH Systemic Inflammatory Response Syndrome
Subject
Poor outcome
Predicate
COEXISTS_WITH
Object
Systemic Inflammatory Response Syndrome
24. Storm NOS PROCESS_OF Patients
Subject
Storm NOS
Predicate
PROCESS_OF
Object
Patients
25. Adjuvant Therapy TREATS Septicemia
Subject
Adjuvant Therapy
Predicate
TREATS
Object
Septicemia
26. cytokine AFFECTS Immune response
Subject
cytokine
Predicate
AFFECTS
Object
Immune response
27. CD69 protein, human|CD69 AFFECTS Immune response
Subject
CD69 protein, human|CD69
Predicate
AFFECTS
Object
Immune response
28. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
29. Storm NOS CAUSES Complication
Subject
Storm NOS
Predicate
CAUSES
Object
Complication
30. adjunctive treatment TREATS Complication
Subject
adjunctive treatment
Predicate
TREATS
Object
Complication
ABSTRACT
The activation of the innate and adaptive immune systems by SARS-CoV-2 causes the release of several inflammatory cytokines, including IL-6. The inflammatory hypercytokinemia causes immunopathological changes in the lungs including vascular leakage, and alveolar edema. As a result of these changes in the lungs, hypoxia and acute respiratory distress syndrome occur in patients with COVID-19. Even though there are clinical trials on the development of therapeutics and vaccines, there are currently no licensed vaccines or therapeutics for COVID-19. Pharmacological approaches have shown poor results in sepsis-like syndromes caused by the hypercytokinemia. Suppressing the cytokine storm is an important way to prevent the organ damage in patients with COVID-19. Extracorporeal blood purification could be proposed as an adjunctive therapy for sepsis, aiming to control the associated dysregulation of the immune system, which is known to protect organ functions. Several extracorporeal blood purification therapies are now available, and most of them target endotoxins and/or the cytokines and aim improving the immune response. For this purpose, plasmapheresis and immunoadsorption may be an important adjunctive treatment option to manage the complications caused by cytokine storm in critically ill patients with COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Plasmapheresis / Coronavirus Infections / Extracorporeal Circulation / Pandemics / Betacoronavirus Type of study: Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Transfus Apher Sci Journal subject: Hematology Year: 2020 Document Type: Article Affiliation country: J.transci.2020.102855

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Plasmapheresis / Coronavirus Infections / Extracorporeal Circulation / Pandemics / Betacoronavirus Type of study: Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Transfus Apher Sci Journal subject: Hematology Year: 2020 Document Type: Article Affiliation country: J.transci.2020.102855