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Elevated Expression of Serum Endothelial Cell Adhesion Molecules in COVID-19 Patients.
Tong, Ming; Jiang, Yu; Xia, Da; Xiong, Ying; Zheng, Qing; Chen, Fang; Zou, Lianhong; Xiao, Wen; Zhu, Yimin.
  • Tong M; Department of Infectious Diseases, Hunan Provincial People's Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.
  • Jiang Y; Institute of Emergency Medicine, Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics, Hunan Provincial People's Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.
  • Xia D; The Fourth People's Hospital of Yiyang, Hunan, China.
  • Xiong Y; The Fourth People's Hospital of Yiyang, Hunan, China.
  • Zheng Q; Department of Geriatrics, Hunan Provincial People's Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.
  • Chen F; Institute of Emergency Medicine, Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics, Hunan Provincial People's Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.
  • Zou L; Institute of Emergency Medicine, Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics, Hunan Provincial People's Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.
  • Xiao W; Institute of Emergency Medicine, Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics, Hunan Provincial People's Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.
  • Zhu Y; Institute of Emergency Medicine, Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics, Hunan Provincial People's Hospital (The First-affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.
J Infect Dis ; 222(6): 894-898, 2020 08 17.
Article in English | MEDLINE | ID: covidwho-613973
ABSTRACT
In a retrospective study of 39 COVID-19 patients and 32 control participants in China, we collected clinical data and examined the expression of endothelial cell adhesion molecules by enzyme-linked immunosorbent assays. Serum levels of fractalkine, vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and vascular adhesion protein-1 (VAP-1) were elevated in patients with mild disease, dramatically elevated in severe cases, and decreased in the convalescence phase. We conclude the increased expression of endothelial cell adhesion molecules is related to COVID-19 disease severity and may contribute to coagulation dysfunction.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cell Adhesion Molecules / Amine Oxidase (Copper-Containing) / Coronavirus Infections / Intercellular Adhesion Molecule-1 / Vascular Cell Adhesion Molecule-1 / Chemokine CX3CL1 / Betacoronavirus Type of study: Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: J Infect Dis Year: 2020 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cell Adhesion Molecules / Amine Oxidase (Copper-Containing) / Coronavirus Infections / Intercellular Adhesion Molecule-1 / Vascular Cell Adhesion Molecule-1 / Chemokine CX3CL1 / Betacoronavirus Type of study: Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: J Infect Dis Year: 2020 Document Type: Article Affiliation country: Infdis