Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient on Ruxolitinib.

Foss, Francine M; Rubinowitz, Ami; Landry, Marie L; Isufi, Iris; Gowda, Lohith; Seropian, Stuart; Perreault, Sarah; Shenoi, Sheela V

Foss, Francine M; Rubinowitz, Ami; Landry, Marie L; Isufi, Iris; Gowda, Lohith; Seropian, Stuart; Perreault, Sarah; Shenoi, Sheela V.

Foss FM; Hematology and Stem Cell Transplantation, Yale University School of Medicine, New Haven, CT. Electronic address: francine.foss@yale.edu.
Rubinowitz A; Yale School of Medicine, Radiology and Biomedical Imaging, New Haven, CT.
Landry ML; Departments of Laboratory Medicine and Medicine, Yale University School of Medicine, New Haven, CT.
Isufi I; Hematology and Stem Cell Transplantation, Yale University School of Medicine, New Haven, CT.
Gowda L; Hematology and Stem Cell Transplantation, Yale University School of Medicine, New Haven, CT.
Seropian S; Hematology and Stem Cell Transplantation, Yale University School of Medicine, New Haven, CT.
Perreault S; Department of Pharmacy, Yale New Haven Hospital, New Haven, CT.
Shenoi SV; Infectious Diseases, Department of Medicine, Yale University School of Medicine, New Haven, CT.

Clin Lymphoma Myeloma Leuk ; 20(11): 720-723, 2020 11.

Article in English | MEDLINE | ID: covidwho-614242

ABSTRACT

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has a high death rate in patients with comorbidities or in an immunocompromised state. We report a mild and attenuated SARS CoV-2 infection in a patient who is 17 months post stem cell transplantation and maintained on the JAK/STAT inhibitor ruxolitinib, a proposed novel therapy for SARS CoV-2 pneumonia.

Subject(s)

Betacoronavirus/immunology; Coronavirus Infections/diagnosis; Graft vs Host Disease/drug therapy; Hematopoietic Stem Cell Transplantation/adverse effects; Pneumonia, Viral/diagnosis; Pyrazoles/therapeutic use; Betacoronavirus/isolation & purification; COVID-19; Coronavirus Infections/drug therapy; Coronavirus Infections/immunology; Coronavirus Infections/virology; Graft vs Host Disease/etiology; Graft vs Host Disease/immunology; Humans; Immunocompromised Host; Lymphoma, T-Cell/immunology; Lymphoma, T-Cell/therapy; Male; Middle Aged; Nitriles; Pandemics; Pneumonia, Viral/drug therapy; Pneumonia, Viral/immunology; Pneumonia, Viral/virology; Pyrimidines; SARS-CoV-2; Severity of Illness Index; Transplantation, Homologous/adverse effects; Treatment Outcome; COVID-19 Drug Treatment

Keywords

Allogeneic stem cell transplantation; COVID-19; Graft-versus-host disease; Immunocompromised; JAK inhibitor

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pyrazoles / Coronavirus Infections / Hematopoietic Stem Cell Transplantation / Betacoronavirus / Graft vs Host Disease Type of study: Case report / Diagnostic study / Prognostic study Limits: Humans / Male / Middle aged Language: English Journal: Clin Lymphoma Myeloma Leuk Journal subject: Neoplasms Year: 2020 Document Type: Article

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