Combined IL-6 and JAK/STAT inhibition therapy in COVID-19-related sHLH, potential game changer.

Portsmore, Sophie; Tran Nguyen, Thien Ngoc; Beacham, Emma; Neelakantan, Pratap

Portsmore, Sophie; Tran Nguyen, Thien Ngoc; Beacham, Emma; Neelakantan, Pratap.

Portsmore S; Royal Berkshire Hospital NHS Foundation Trust, Reading, UK.
Tran Nguyen TN; Royal Berkshire Hospital NHS Foundation Trust, Reading, UK.
Beacham E; Royal Berkshire Hospital NHS Foundation Trust, Reading, UK.
Neelakantan P; Royal Berkshire Hospital NHS Foundation Trust, Reading, UK.

Br J Haematol ; 190(4): 525-528, 2020 08.

Article in English | MEDLINE | ID: covidwho-614299

Subject(s)

Antibodies, Monoclonal, Humanized/administration & dosage; COVID-19 Drug Treatment; COVID-19; Interleukin-6/antagonists & inhibitors; Janus Kinases/antagonists & inhibitors; Lymphohistiocytosis, Hemophagocytic; Pyrazoles/administration & dosage; SARS-CoV-2; STAT Transcription Factors/analysis; Aged; COVID-19/blood; COVID-19/complications; COVID-19/diagnostic imaging; Drug Therapy, Combination; Female; Humans; Lymphohistiocytosis, Hemophagocytic/blood; Lymphohistiocytosis, Hemophagocytic/diagnostic imaging; Lymphohistiocytosis, Hemophagocytic/drug therapy; Lymphohistiocytosis, Hemophagocytic/etiology; Male; Middle Aged; Nitriles; Pyrimidines

Keywords

Ruxolitinib; Tocilizumab; cytokine storm; secondary haemophagocytic lymphohistiocytosis; severe COVID

Fulltext

XML

PubMed Links

Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pyrazoles / Interleukin-6 / Lymphohistiocytosis, Hemophagocytic / STAT Transcription Factors / Janus Kinases / Antibodies, Monoclonal, Humanized / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment Type of study: Case report Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Br J Haematol Year: 2020 Document Type: Article Affiliation country: Bjh.16966

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

PubMed Links

Search on Google