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Primary Symptoms, Comorbidities, and Outcomes of 431 Hospitalized Patients with Confirmative RT-PCR Results for COVID-19.
Norooznezhad, Amir Hossein; Najafi, Farid; Riahi, Parisa; Moradinazar, Mehdi; Shakiba, Ebrahim; Mostafaei, Shayan.
  • Norooznezhad AH; 1Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Najafi F; 2Research Center for Environmental Determinants of Health (RCEDH), Health Institute, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Riahi P; 3Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
  • Moradinazar M; 2Research Center for Environmental Determinants of Health (RCEDH), Health Institute, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Shakiba E; 2Research Center for Environmental Determinants of Health (RCEDH), Health Institute, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Mostafaei S; 4Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Am J Trop Med Hyg ; 103(2): 834-837, 2020 08.
Article in English | MEDLINE | ID: covidwho-614631
ABSTRACT
This study aimed to evaluate the primary symptoms, comorbidities, and outcomes of inpatients with confirmed reverse transcription-PCR (RT-PCR) for SARS-CoV-2 infection among 2077 suspected/diagnosed cases of COVID-19. Based on the results of Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression, age, and suggestive chest X-ray (CXR) findings for SARS-CoV-2 infection, cardiovascular diseases, diabetes mellitus, chronic lung diseases, and intensive care units admission had significant associations with positive RT-PCR results for COVID-19 infection. Also, the highest area under the curve (AUC) was related to cough (AUC = 0.53, 95% CI 0.51-0.56), dyspnea (AUC = 0.52, 95% CI 0.50-0.54), and abnormal CXR (AUC = 0.52, 95% CI 0.50-0.54), as significant predictors. This study showed that some symptoms including cough and dyspnea, as well as abnormal CXR, could be proper predictors of positive RT-PCR result for SARS-CoV-2 infection. It seems that patients with underlying disease(s), such as cardiovascular diseases, diabetes mellitus, and chronic lung diseases, had a higher probability to have positive RT-PCR for SARS-CoV-2 infection than those with no underlying disease(s).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Comorbidity / Coronavirus Infections / Reverse Transcriptase Polymerase Chain Reaction Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Child / Humans / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Am J Trop Med Hyg Year: 2020 Document Type: Article Affiliation country: Ajtmh.20-0512

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Comorbidity / Coronavirus Infections / Reverse Transcriptase Polymerase Chain Reaction Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Child / Humans / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Am J Trop Med Hyg Year: 2020 Document Type: Article Affiliation country: Ajtmh.20-0512