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Relationship Between ACE2 and Other Components of the Renin-Angiotensin System.
Cohen, Jordana B; Hanff, Thomas C; Bress, Adam P; South, Andrew M.
  • Cohen JB; Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jco@pennmedicine.upenn.edu.
  • Hanff TC; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. jco@pennmedicine.upenn.edu.
  • Bress AP; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • South AM; Division of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Curr Hypertens Rep ; 22(7): 44, 2020 06 26.
Article in English | MEDLINE | ID: covidwho-615149
ABSTRACT
PURPOSE OF THE REVIEW Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection. RECENT

FINDINGS:

ACE2 converts angiotensin (Ang) II to Ang-(1-7), which directly opposes the vasoconstrictive, proinflammatory, and prothrombotic effects of Ang II. ACE2 also facilitates SARS-CoV-2 viral entry into host cells. Drugs that interact with the renin-angiotensin system may impact ACE2 expression and COVID-19 pathogenesis; however, the magnitude and direction of these effects are unknown at this time. High quality research is needed to improve our understanding of how agents that act on the renin-angiotensin system impact ACE2 and COVID-19-related disease outcomes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Renin-Angiotensin System / Coronavirus Infections / Peptidyl-Dipeptidase A Limits: Humans Language: English Journal: Curr Hypertens Rep Journal subject: Vascular Diseases Year: 2020 Document Type: Article Affiliation country: S11906-020-01048-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Renin-Angiotensin System / Coronavirus Infections / Peptidyl-Dipeptidase A Limits: Humans Language: English Journal: Curr Hypertens Rep Journal subject: Vascular Diseases Year: 2020 Document Type: Article Affiliation country: S11906-020-01048-y