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Immune response in children with COVID-19 is characterized by lower levels of T-cell activation than infected adults.
Moratto, Daniele; Giacomelli, Mauro; Chiarini, Marco; Savarè, Lucia; Saccani, Barbara; Motta, Mario; Timpano, Silviana; Poli, Piercarlo; Paghera, Simone; Imberti, Luisa; Cannizzo, Stefania; Quiros-Roldan, Eugenia; Marchetti, Giulia; Badolato, Raffaele.
  • Moratto D; From Flow Cytometry Laboratory, Clinical Chemistry Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy.
  • Giacomelli M; Department of Clinical and Experimental Sciences, University of Brescia and A. Nocivelli Institute of Molecular Medicine, Brescia, Italy.
  • Chiarini M; From Flow Cytometry Laboratory, Clinical Chemistry Laboratory, ASST Spedali Civili di Brescia, Brescia, Italy.
  • Savarè L; Department of Clinical and Experimental Sciences, University of Brescia and A. Nocivelli Institute of Molecular Medicine, Brescia, Italy.
  • Saccani B; Infectious Diseases, University of Brescia, Brescia, Italy.
  • Motta M; Neonatology, University of Brescia, Brescia, Italy.
  • Timpano S; Cystic Fibrosis and Pneumology Center, University of Brescia, Brescia, Italy.
  • Poli P; Cystic Fibrosis and Pneumology Center, University of Brescia, Brescia, Italy.
  • Paghera S; Laboratorio CREA, ASST Spedali Civili, University of Brescia, Brescia, Italy.
  • Imberti L; Laboratorio CREA, ASST Spedali Civili, University of Brescia, Brescia, Italy.
  • Cannizzo S; Infectious Diseases, University of Milan, Milan, Italy.
  • Quiros-Roldan E; Infectious Diseases, University of Brescia, Brescia, Italy.
  • Marchetti G; Infectious Diseases, University of Milan, Milan, Italy.
  • Badolato R; Department of Clinical and Experimental Sciences, University of Brescia and A. Nocivelli Institute of Molecular Medicine, Brescia, Italy.
Eur J Immunol ; 50(9): 1412-1414, 2020 09.
Article in English | MEDLINE | ID: covidwho-615368
ABSTRACT
Study of immunological features of immune response in 14 children (aged from 12 days up to 15 years) and of 10 adults who developed COVID-19 show increased number of activated CD4 and CD8 cells expressing DR and higher plasmatic levels of IL-12 and IL-1ß in adults with COVID-19, but not in children. In addition, plasmatic levels of CCL5/RANTES are higher in children and adults with COVID-19, while CXCL9/MIG was only increased in adults. Higher number of activated T cells and expression of IL-12 and CXCL9 suggest prominent Th1 polarization of immune response against SARS-CoV2 in infected adults as compared with children.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / Chemokines / SARS-CoV-2 / COVID-19 Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Language: English Journal: Eur J Immunol Year: 2020 Document Type: Article Affiliation country: Eji.202048724

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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / Chemokines / SARS-CoV-2 / COVID-19 Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Language: English Journal: Eur J Immunol Year: 2020 Document Type: Article Affiliation country: Eji.202048724