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Intestinal Flora as a Potential Strategy to Fight SARS-CoV-2 Infection.
He, Li-Hong; Ren, Long-Fei; Li, Jun-Feng; Wu, Yong-Na; Li, Xun; Zhang, Lei.
  • He LH; The First Clinical Medical College, Lanzhou University, Lanzhou, China.
  • Ren LF; Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China.
  • Li JF; Key Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu Province, Lanzhou, China.
  • Wu YN; The First Clinical Medical College, Lanzhou University, Lanzhou, China.
  • Li X; Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China.
  • Zhang L; Key Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu Province, Lanzhou, China.
Front Microbiol ; 11: 1388, 2020.
Article in English | MEDLINE | ID: covidwho-615531
ABSTRACT
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly worldwide, seriously endangering human health. In addition to the typical symptoms of pulmonary infection, patients with COVID-19 have been reported to have gastrointestinal symptoms and/or intestinal flora dysbiosis. It is known that a healthy intestinal flora is closely related to the maintenance of pulmonary and systemic health by regulating the host immune homeostasis. Role of the "gut-lung axis" has also been well-articulated. This review provides a novel suggestion that intestinal flora may be one of the mediators of the gastrointestinal responses and abnormal immune responses in hosts caused by SARS-CoV-2; improving the composition of intestinal flora and the proportion of its metabolites through probiotics, and personalized diet could be a potential strategy to prevent and treat COVID-19. More clinical and evidence-based medical trials may be initiated to determine the strategy.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Front Microbiol Year: 2020 Document Type: Article Affiliation country: Fmicb.2020.01388

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Front Microbiol Year: 2020 Document Type: Article Affiliation country: Fmicb.2020.01388