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Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19.
Narasaraju, Teluguakula; Tang, Benjamin M; Herrmann, Martin; Muller, Sylviane; Chow, Vincent T K; Radic, Marko.
  • Narasaraju T; College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, United States.
  • Tang BM; Department of Intensive Care Medicine, Nepean Hospital, Sydney, NSW, Australia.
  • Herrmann M; Department of Internal Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
  • Muller S; CNRS-University of Strasbourg, Biotechnology and Cell Signaling, Illkirch, France.
  • Chow VTK; Laboratory of Excellence Medalis, Institut de science et d'ingénierie supramoléculaire, and University of Strasbourg Institute for Advanced Study (USIAS), Strasbourg, France.
  • Radic M; Department of Microbiology and Immunology, Infectious Diseases Program, School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.
Front Pharmacol ; 11: 870, 2020.
Article in English | MEDLINE | ID: covidwho-615558
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Malaise PROCESS_OF Patients
Subject
Malaise
Predicate
PROCESS_OF
Object
Patients
3. cytokine ASSOCIATED_WITH COVID-19
Subject
cytokine
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ASSOCIATED_WITH
Object
COVID-19
4. Mechanical devices USES Mechanical Ventilator
Subject
Mechanical devices
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USES
Object
Mechanical Ventilator
5. Mechanical devices TREATS Respiratory Distress Syndrom
Subject
Mechanical devices
Predicate
TREATS
Object
Respiratory Distress Syndrom
6. Respiratory Distress Syndrom COEXISTS_WITH C5203670
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Respiratory Distress Syndrom
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7. Therapeutic procedure TREATS Respiratory Distress Syndrom
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TREATS
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Respiratory Distress Syndrom
8. Respiratory Distress Syndrom PROCESS_OF C0030705
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Respiratory Distress Syndrom
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9. COVID-19 PROCESS_OF Patients
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COVID-19
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PROCESS_OF
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Patients
10. Malaise PROCESS_OF Patients
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Malaise
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PROCESS_OF
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Patients
11. cytokine ASSOCIATED_WITH COVID-19
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cytokine
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COVID-19
12. Mechanical devices USES Mechanical Ventilator
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Mechanical devices
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Mechanical Ventilator
13. Mechanical devices TREATS Respiratory Distress Syndrome, Adult
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Mechanical devices
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TREATS
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Respiratory Distress Syndrome, Adult
14. Respiratory Distress Syndrome, Adult COEXISTS_WITH COVID-19
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Respiratory Distress Syndrome, Adult
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COEXISTS_WITH
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COVID-19
15. Therapeutic procedure TREATS Respiratory Distress Syndrome, Adult
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Therapeutic procedure
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TREATS
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Respiratory Distress Syndrome, Adult
16. Respiratory Distress Syndrome, Adult PROCESS_OF Patients
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Respiratory Distress Syndrome, Adult
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ABSTRACT
There is an urgent need for new therapeutic strategies to contain the spread of the novel coronavirus disease 2019 (COVID-19) and to curtail its most severe complications. Severely ill patients experience pathologic manifestations of acute respiratory distress syndrome (ARDS), and clinical reports demonstrate striking neutrophilia, elevated levels of multiple cytokines, and an exaggerated inflammatory response in fatal COVID-19. Mechanical respirator devices are the most widely applied therapy for ARDS in COVID-19, yet mechanical ventilation achieves strikingly poor survival. Many patients, who recover, experience impaired cognition or physical disability. In this review, we argue the need to develop therapies aimed at inhibiting neutrophil recruitment, activation, degranulation, and neutrophil extracellular trap (NET) release. Moreover, we suggest that currently available pharmacologic approaches should be tested as treatments for ARDS in COVID-19. In our view, targeting host-mediated immunopathology holds promise to alleviate progressive pathologic complications of ARDS and reduce morbidities and mortalities in severely ill patients with COVID-19.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Front Pharmacol Year: 2020 Document Type: Article Affiliation country: Fphar.2020.00870

Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Front Pharmacol Year: 2020 Document Type: Article Affiliation country: Fphar.2020.00870