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Effect of lopinavir/ritonavir on blood lipid levels in patients with coronavirus disease 2019
Medical Journal of Wuhan University ; 41(4):565-567, 2020.
Article | COVIDWHO | ID: covidwho-616542
ABSTRACT

Objective:

To study the effect of lopinavir/ritonavir on blood lipid levels in the treatment of patients with coronavirus disease 2019 (COVID-19)

Methods:

Forty COVID-19 patients admitted to the First Ward of Hubei Shiyan Second Medical Treatment Hospital from February 3 to February 6, 2020 Among them, 34 patients were tested for blood lipids before oral lopinavir/ritonavir The blood lipid changes were observed during the treatment of oral lopinavir/ritonavir

Results:

The blood lipid levels of 34 patients who underwent oral lopinavir/ritonavir treatment for 7-10 days were higher than those before treatment with significant difference Among the 34 patients, fourteen patients showed significantly increased blood lipid levels after oral lopinavir/ritonavir (9-10 days of treatment), and their blood lipid levels were re-assayed 3-5 days after lopinavir/ritonavir discontinuance The overall levels of triglyceride and cholesterol were still elevated, but the difference was not statistically significant

Conclusion:

Lopinavir/ritonavir has a significant effect on blood lipid levels in patients with COVID-19 Blood lipid levels should be monitored regularly and intervention measures should be given in time to prevent cardiovascular, cerebrovascular, and other possible complications © 2020, Editorial Board of Medical Journal of Wuhan University All right reserved

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Full text: Available Index: COVIDWHO Type: Article Journal: Medical Journal of Wuhan University Year: 2020