Clinical characteristics, treatment, and prognosis in 89 cases of COVID-19

ABSTRACT

Objective: To investigate the clinical characteristics, treatment and prognosis of novel coronavirus pneumonia (COVID-19). Methods: A total of 89 cases COVID-19 patients in Renmin Hospital of Wuhan University from January 17, 2020 to February 20, 2020 were analyzed retrospectively, and the clinical characteristics, course of treatment and prognosis were summarized. Results: According to the guideline for Diagnosis and Treatment of Novel Coronavirus Infected Pneumonia, 89 cases were divided into mild group (n=18, 20.2%), common group (n=40, 44.9%), severe group (n=21, 23.6%), and critical group (n=10, 11.2%). There were significant differences in the incidence of fever, dry cough and dyspnea among the four groups (P0.05). Compared with those in mild group, white blood cell count (WBC), neutrophil count (NEUT), lymphocyte count (LYM), and monocyte count (MONO) increased significantly in the other three groups, while the serum levels of C-reactive protein (CRP), procalcitonin (PCT), creatinine (Cr), urea nitrogen (Urea) and troponin I (cTnI) increased significantly in severe and critical groups (P0.05). Compared with those in common group, the LYM of the severe and the critical patients were significantly lower, while the CRP, Cr, urea and cTnI levels increased significantly (P0.05). Among the 89 patients, 6 patients (6.7%) had acute myocardial injury, 6 patients (6.7%) had respiratory failure, 3 patients (3.4%) had renal failure, and 3 patients had shock (3.4%). There were significant differences in myocardial injury, respiratory failure, and shock incidences among the four groups (P0.05). Among the 89 patients, 7 patients (7.9%) were died, 82 patients (92.1%) were cured and discharged from hospital. Among them, there was no death in mild group, 1 patient (2.5%) was died in common group, 3 patients (14.3%) were died in severe group, and 3 patients (30.0%) were died in critical group. There was a significant difference in mortality among the four groups (P0.05). Conclusion: COVID-19 patients in severe and critical classification are more serious in inflammatory reaction, and more prone to myocardial injury, respiratory failure and shock. © 2020, Editorial Board of Medical Journal of Wuhan University. All right reserved.