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A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques.
van Doremalen, Neeltje; Haddock, Elaine; Feldmann, Friederike; Meade-White, Kimberly; Bushmaker, Trenton; Fischer, Robert J; Okumura, Atsushi; Hanley, Patrick W; Saturday, Greg; Edwards, Nick J; Clark, Madeleine H A; Lambe, Teresa; Gilbert, Sarah C; Munster, Vincent J.
  • van Doremalen N; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.
  • Haddock E; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.
  • Feldmann F; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
  • Meade-White K; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.
  • Bushmaker T; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.
  • Fischer RJ; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.
  • Okumura A; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
  • Hanley PW; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
  • Saturday G; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
  • Edwards NJ; The Jenner Institute, University of Oxford, Oxford, UK.
  • Clark MHA; The Jenner Institute, University of Oxford, Oxford, UK.
  • Lambe T; Transmission Biology Group, The Pirbright Institute, Pirbright, Woking, UK.
  • Gilbert SC; The Jenner Institute, University of Oxford, Oxford, UK.
  • Munster VJ; The Jenner Institute, University of Oxford, Oxford, UK.
Sci Adv ; 6(24): eaba8399, 2020 06.
Article in English | MEDLINE | ID: covidwho-617060
Semantic information from SemMedBD (by NLM)
1. Immunity PROCESS_OF Macaca mulatta
Subject
Immunity
Predicate
PROCESS_OF
Object
Macaca mulatta
2. Structure of parenchyma of lung LOCATION_OF Pneumonia
Subject
Structure of parenchyma of lung
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LOCATION_OF
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Pneumonia
3. Alveolar Epithelial Cells PART_OF Animals
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Alveolar Epithelial Cells
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PART_OF
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Animals
4. Middle East Respiratory Syndrome PROCESS_OF Macaca mulatta
Subject
Middle East Respiratory Syndrome
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PROCESS_OF
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Macaca mulatta
5. Immunity PROCESS_OF Macaca mulatta
Subject
Immunity
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PROCESS_OF
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Macaca mulatta
6. Structure of parenchyma of lung LOCATION_OF Pneumonia
Subject
Structure of parenchyma of lung
Predicate
LOCATION_OF
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Pneumonia
7. Alveolar Epithelial Cells PART_OF Animals
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Alveolar Epithelial Cells
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PART_OF
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Animals
8. Middle East Respiratory Syndrome PROCESS_OF Macaca mulatta
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Middle East Respiratory Syndrome
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PROCESS_OF
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Macaca mulatta
ABSTRACT
Developing a vaccine to protect against the lethal effects of the many strains of coronavirus is critical given the current global pandemic. For Middle East respiratory syndrome coronavirus (MERS-CoV), we show that rhesus macaques seroconverted rapidly after a single intramuscular vaccination with ChAdOx1 MERS. The vaccine protected against respiratory injury and pneumonia and reduced viral load in lung tissue by several orders of magnitude. MERS-CoV replication in type I and II pneumocytes of ChAdOx1 MERS-vaccinated animals was absent. A prime-boost regimen of ChAdOx1 MERS boosted antibody titers, and viral replication was completely absent from the respiratory tract tissue of these rhesus macaques. We also found that antibodies elicited by ChAdOx1 MERS in rhesus macaques neutralized six different MERS-CoV strains. Transgenic human dipeptidyl peptidase 4 mice vaccinated with ChAdOx1 MERS were completely protected against disease and lethality for all different MERS-CoV strains. The data support further clinical development of ChAdOx1 MERS.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / Vaccination / Middle East Respiratory Syndrome Coronavirus / Immunogenicity, Vaccine Topics: Vaccines Limits: Animals / Female / Humans / Male Language: English Journal: Sci Adv Year: 2020 Document Type: Article Affiliation country: Sciadv.aba8399

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / Vaccination / Middle East Respiratory Syndrome Coronavirus / Immunogenicity, Vaccine Topics: Vaccines Limits: Animals / Female / Humans / Male Language: English Journal: Sci Adv Year: 2020 Document Type: Article Affiliation country: Sciadv.aba8399