Patterns of liver injury in COVID-19 - a German case series.
United European Gastroenterol J
; 8(7): 814-819, 2020 08.
Article
in English
| MEDLINE | ID: covidwho-617210
ABSTRACT
BACKGROUND:
Reports of liver injury in patients with novel coronavirus disease 2019 (COVID-19) are emerging from China and the USA. A wide variety of liver function test abnormalities and few cases of severe liver failure have been reported. No data on the hepatic phenotype from Europe are available at current.METHODS:
We report a case series of 44 consecutive patients hospitalized for COVID-19 in Germany.RESULTS:
At the time of admission, aspartate aminotransferase greater than the upper limit of normal was present in 70%, while alanine aminotransferase was elevated in 15.8%. Markers of cholestatic liver injury were altered only in a minority of patients. During hospitalization, 31% and 22% experienced increasing aspartate aminotransferase and alanine aminotransferase, respectively, when transaminases were normal at admission. Severe liver injury defined by 3×> upper limit of normal was observed in 9.1% over a mean time of 10.5 days. Importantly, patients exhibited cytotoxicity including lactate dehydrogenase and creatinine kinase elevations, but no signs of relevant liver function impairment.CONCLUSION:
In summary, in a case series of hospitalized patients in Germany, cytotoxicity in the absence of severe liver dysfunction at admission and only few cases suggestive of severe liver injury during hospital were observed.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Pneumonia, Viral
/
Liver Failure, Acute
/
Coronavirus Infections
/
Chemical and Drug Induced Liver Injury
/
Betacoronavirus
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Country/Region as subject:
Europa
Language:
English
Journal:
United European Gastroenterol J
Year:
2020
Document Type:
Article
Affiliation country:
2050640620931657
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