Your browser doesn't support javascript.
Association between obesity and clinical prognosis in patients infected with SARS-CoV-2.
Cai, Shao-Hang; Liao, Wei; Chen, Shu-Wei; Liu, Li-Li; Liu, Si-Yao; Zheng, Zhi-Dan.
  • Cai SH; Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China. shaohangcai@foxmail.com.
  • Liao W; Intensive Care Unit, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China.
  • Chen SW; Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong Province, China.
  • Liu LL; Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong Province, China.
  • Liu SY; Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China.
  • Zheng ZD; Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong Province, China.
Infect Dis Poverty ; 9(1): 80, 2020 Jun 29.
Article in English | MEDLINE | ID: covidwho-617267
ABSTRACT

BACKGROUND:

It is well established that obesity is a disease of sustained low-grade inflammation. However, it is currently unknown if obesity plays a role in the clinical manifestations and prognosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. In this study, we aimed to investigate whether obesity played a role in clinical manifestations and prognosis in patients infected with SARS-CoV-2.

METHODS:

This is a retrospective multicenter clinical study. A total of 96 patients hospitalized with SARS-CoV-2 infection were enrolled from Dongguan People's Hospital, Nanfang hospital and the First Affiliated Hospital of Xiamen University between 23 January and 14 February 2020. Demographic and clinical data were extracted from medical records. Acute respiratory distress syndrome (ARDS) was defined as oxygenation index (PaO2/FiO2) ≤ 300 mmHg. We grouped patients through the body mass index (BMI). Associations were examined using the t test, χ2 test and multivariate logistic forward regression test.

RESULTS:

Patients with BMI <  24 were significantly younger (P = 0.025) with lower creatine kinase (P = 0.013), lower diastolic pressure blood (P = 0.035), lower serum creatinine (P = 0.012), lower lactate dehydrogenase (P = 0.001) and higher platelet count (P = 0.002). The BMI level was 20.78 ± 3.15 in patients without pneumonia compared with the patients with pneumonia (23.81 ± 3.49, P = 0.001). For patients without ARDS, an average BMI level of 22.65 ± 3.53 was observed, significantly lower than patients with ARDS (24.57 ± 3.59, P = 0.022). The mean BMI was 22.35 ± 3.56 in patients experienced with relieving the clinical symptoms or stable condition by radiographic tests, lower than patients with disease exacerbation with 24.89 ± 3.17 (P = 0.001). In addition, lymphocyte count (r = - 0.23, P = 0.027) and platelet count (r = - 0.44, P < 0.001) were negatively correlated with BMI. While hemoglobin (r = 0.267, P = 0.008), creatine kinase (r = 0.331, P = 0.001), serum creatinine (r = 0.424, P < 0.001) and lactate dehydrogenase (r = 0.343, P = 0.001) were significantly positive correlated with BMI. Multivariate analysis showed that older age (OR = 1.046, P = 0.009) and BMI ≥ 24 (OR = 1.258, P = 0.005) were independent risk factors associated ICU admission while BMI ≥ 24 (OR = 4.219, P = 0.007) was independent risk factor associated with radiographic disease exacerbation.

CONCLUSIONS:

Our study found BMI was significantly associated with clinical manifestations and prognosis of patients with SARS-CoV-2 infection. For patients with increased risk, clinicians should intervene promptly to avoid disease progression.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus / Obesity Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid / Variants Limits: Adolescent / Adult / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Infect Dis Poverty Year: 2020 Document Type: Article Affiliation country: S40249-020-00703-5

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus / Obesity Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid / Variants Limits: Adolescent / Adult / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Infect Dis Poverty Year: 2020 Document Type: Article Affiliation country: S40249-020-00703-5