Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection.
J Transl Med
; 18(1): 261, 2020 06 29.
Article
in English
| MEDLINE | ID: covidwho-617269
ABSTRACT
Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms (1) as immunostimulants which could boost γδ T cell expansion, important in the acute response in the lung; (2) as DC modulators, limiting their ability to only partially activate T cells; and (3) as prenylation inhibitors of small GTPases in the endosomal pathway of the DC to prevent expulsion of lysosomes containing SARS-CoV-2 virions. Use of ZA or other amino-bisphosphonates as modulators of COVID-19 disease should be considered.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Endosomes
/
Dendritic Cells
/
Coronavirus Infections
/
Diphosphonates
/
Betacoronavirus
/
Immunologic Factors
Limits:
Animals
/
Humans
Language:
English
Journal:
J Transl Med
Year:
2020
Document Type:
Article
Affiliation country:
S12967-020-02433-6
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