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Genetic variants that influence SARS-CoV-2 receptor TMPRSS2 expression among population cohorts from multiple continents.
Irham, Lalu Muhammad; Chou, Wan-Hsuan; Calkins, Marcus J; Adikusuma, Wirawan; Hsieh, Shie-Liang; Chang, Wei-Chiao.
  • Irham LM; Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, 11031, Taiwan; Faculty of Pharmacy, University of Ahmad Dahlan, Yogyakarta, 55164, Indonesia.
  • Chou WH; Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, 11031, Taiwan; Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei, 11031, Taiwan.
  • Calkins MJ; Institute of Cellular and Organismic Biology, Academia Sincia, Taipei, 11529, Taiwan.
  • Adikusuma W; Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, 11031, Taiwan.
  • Hsieh SL; Genomics Research Center, Academia Sinica, Taipei, 11529, Taiwan.
  • Chang WC; Department of Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, 11031, Taiwan; Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei, 11031, Taiwan; Integrative Research Center for Criti
Biochem Biophys Res Commun ; 529(2): 263-269, 2020 08 20.
Article in English | MEDLINE | ID: covidwho-617705
ABSTRACT
The World Health Organization recently announced that pandemic status has been achieved for coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Exponential increases in patient numbers have been reported around the world, along with proportional increases in the number of COVID-19-related deaths. The SARS-CoV-2 infection rate in a population is expected to be influenced by social practices, availability of vaccines or prophylactics, and the prevalence of susceptibility genes in the population. Previous work revealed that cellular uptake of SARS-CoV-2 requires Angiotensin Converting Enzyme 2 (ACE-2) and a cellular protease. The spike (S) protein on SARS-CoV-2 binds ACE-2, which functions as an entry receptor. Following receptor binding, transmembrane protease serine 2 (encoded by TMPRSS2) primes the S protein to allow cellular uptake. Therefore, individual expression of TMPRSS2 may be a crucial determinant of SARS-CoV-2 infection susceptibility. Here, we utilized multiple large genome databases, including the GTEx portal, SNP nexus, and Ensembl genome project, to identify gene expression profiles for TMPRSS2 and its important expression quantitative trait loci. Our results show that four variants (rs464397, rs469390, rs2070788 and rs383510) affect expression of TMPRSS2 in lung tissue. The allele frequency of each variant was then assessed in regional populations, including African, American, European, and three Asian cohorts (China, Japan and Taiwan). Interestingly, our data shows that TMPRSS2-upregulating variants are at higher frequencies in European and American populations than in the Asian populations, which implies that these populations might be relatively susceptible to SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Virus / Serine Endopeptidases / Gene Expression Regulation / Internationality / Betacoronavirus / Lung Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: North America / Asia / Europa Language: English Journal: Biochem Biophys Res Commun Year: 2020 Document Type: Article Affiliation country: J.bbrc.2020.05.179

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Virus / Serine Endopeptidases / Gene Expression Regulation / Internationality / Betacoronavirus / Lung Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: North America / Asia / Europa Language: English Journal: Biochem Biophys Res Commun Year: 2020 Document Type: Article Affiliation country: J.bbrc.2020.05.179