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Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019.
Lechien, Jerome R; Chiesa-Estomba, Carlos M; Place, Sammy; Van Laethem, Yves; Cabaraux, Pierre; Mat, Quentin; Huet, Kathy; Plzak, Jan; Horoi, Mihaela; Hans, Stéphane; Rosaria Barillari, Maria; Cammaroto, Giovanni; Fakhry, Nicolas; Martiny, Delphine; Ayad, Tareck; Jouffe, Lionel; Hopkins, Claire; Saussez, Sven.
  • Lechien JR; From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.
  • Chiesa-Estomba CM; Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.
  • Place S; Department of Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.
  • Van Laethem Y; Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.
  • Cabaraux P; From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.
  • Mat Q; Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain.
  • Huet K; From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.
  • Plzak J; Department of Internal Medicine, Infectiology, EpiCURA Hospital, Baudour, Belgium.
  • Horoi M; Department of Internal Medicine, Infectiology, CHU Saint-Pierre, Brussels, Belgium.
  • Hans S; From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.
  • Rosaria Barillari M; Department of Medicine, Neurology, CHU de Charleroi, Charleroi, Belgium.
  • Cammaroto G; From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.
  • Fakhry N; Department of Medicine, Neurology, CHU de Charleroi, Charleroi, Belgium.
  • Martiny D; From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.
  • Ayad T; Department of Statistics, Language Sciences, University of Mons, Mons, Belgium.
  • Jouffe L; Department of Otolaryngology - Head & Neck Surgery, 1st Faculty of Medicine, University Hospital Motol, Prague, Czech Republic.
  • Hopkins C; Confederation of European Otorhinolaryngology-Head & Neck Surgery, Vienna, Austria.
  • Saussez S; From, COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France.
J Intern Med ; 288(3): 335-344, 2020 09.
Article in English | MEDLINE | ID: covidwho-618315
ABSTRACT

BACKGROUND:

The clinical presentation of European patients with mild-to-moderate COVID-19 infection is still unknown.

OBJECTIVE:

To study the clinical presentation of COVID-19 in Europe.

METHODS:

Patients with positive diagnosis of COVID-19 were recruited from 18 European hospitals. Epidemiological and clinical data were obtained through a standardized questionnaire. Bayesian analysis was used for analysing the relationship between outcomes.

RESULTS:

A total of 1,420 patients completed the study (962 females, 30.7% of healthcare workers). The mean age of patients was 39.17 ± 12.09 years. The most common symptoms were headache (70.3%), loss of smell (70.2%), nasal obstruction (67.8%), cough (63.2%), asthenia (63.3%), myalgia (62.5%), rhinorrhea (60.1%), gustatory dysfunction (54.2%) and sore throat (52.9%). Fever was reported by 45.4%. The mean duration of COVID-19 symptoms of mild-to-moderate cured patients was 11.5 ± 5.7 days. The prevalence of symptoms significantly varied according to age and sex. Young patients more frequently had ear, nose and throat complaints, whereas elderly individuals often presented fever, fatigue and loss of appetite. Loss of smell, headache, nasal obstruction and fatigue were more prevalent in female patients. The loss of smell was a key symptom of mild-to-moderate COVID-19 patients and was not associated with nasal obstruction and rhinorrhea. Loss of smell persisted at least 7 days after the disease in 37.5% of cured patients.

CONCLUSION:

The clinical presentation of mild-to-moderate COVID-19 substantially varies according to the age and the sex characteristics of patients. Olfactory dysfunction seems to be an important underestimated symptom of mild-to-moderate COVID-19 that needs to be recognized as such by the WHO.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Taste Disorders / Coronavirus Infections / Betacoronavirus / Headache / Olfaction Disorders Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Intern Med Journal subject: Internal Medicine Year: 2020 Document Type: Article Affiliation country: Joim.13089

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Taste Disorders / Coronavirus Infections / Betacoronavirus / Headache / Olfaction Disorders Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Intern Med Journal subject: Internal Medicine Year: 2020 Document Type: Article Affiliation country: Joim.13089