Potential role of endothelial cell surface ectopic redox complexes in COVID-19 disease pathogenesis.
Clin Med (Lond)
; 20(5): e146-e147, 2020 09.
Article
in English
| MEDLINE | ID: covidwho-620429
ABSTRACT
The novel coronavirus infectious disease (COVID-19) has rapidly spread and poses a great challenge to researchers, both in elucidating its pathogenic mechanism and developing effective treatments. It has been recently proposed that COVID-19 is an endothelial disease. Indeed, the COVID-19 virus binds to angiotensin-converting enzyme type 2 (ACE2), which is expressed in endothelial cells. ACE2 could be implicated in the production of reactive oxygen species (ROS) caused by endothelial dysfunction due to viral damage. Consequently, oxidative stress could prime these cells to acquire a pro-thrombotic and pro-inflammatory phenotype, predisposing patients to thromboembolic and vasculitic events and to disseminated intravascular coagulopathy (DIC). This implies a pivotal role played by oxygen in the pathogenetic mechanism of COVID-19 disease, in that its availability would tune the oxidant state and consequent damage.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Endothelium, Vascular
/
Coronavirus Infections
/
Severe Acute Respiratory Syndrome
/
Endothelial Cells
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Clin Med (Lond)
Year:
2020
Document Type:
Article
Affiliation country:
Clinmed.2020-0252
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