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Can Yin-Chai-Xiao-Du decoction be useful of COVID-19? the mechanism research based on network pharmacology
Coronavirus disease 2019 Bupleuri radix Scutellariae radix Artemisiae annuae herba Cytokine Storm Tumor necrosis factor Interleukin-6 kappa-b pathways inflammatory response cytokine storms inhibition activation luteolin relaxin mapk mice Integrative & Complementary Medicine ; 2020(Traditional Medicine Research): en,
Article in ISI Document delivery No.: LY8VM Times Cited: 0 Cited Reference Count: 50 Yang Lu Li Ning Hu Hai-Bo Yin Bin zhao Guo-Jing Wang Fen-zhan Wang Xu-Hui Wang Hong-Wu Lu Xue-zhao Cui Huan-Tian National Key Researzh and development Program [2018YFC1704800] | Jul | ID: covidwho-621315
ABSTRACT

Background:

In this study, we preliminarily investigated the mechanism of Yin-Chai-Xiao-Du decoction for the treatment of COVID-19 by the method of network pharmacology.

Methods:

The potential targets and pathways of Yin-Chai-Xiao-Du decoction for the treatment of COVID-19 were examined using network pharmacology;the ingredient and active targets of Yin-Chai-Xiao-Du decoction were collected from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and PharmMapper databases;the COVID-19-related targets were obtained from the online Mendelian inheritance in man, GeneCards, and GeneMANIA databases;the STRING database and Cytoscape were used to build a protein-protein interaction network, and a Network Analyzer tool was used to perform topology analysis to screen for the key ingredients and targets;the ClueGO and KOBAS 3.0 databases were for the enrichment analysis of gene function (Gene Oncology) and gene pathway (Kyoto Encyclopedia of Genes and Genomes);the herb-ingredient-target-pathway network diagram was constructed by Cytoscape.

Results:

The core herbs screened by the network pharmacological analysis were Jinyinhua (Lonicerae japonicae flos), Lianqiao (Forsythia suspensa), Chaihu (Bupleuri radix), Huangqin (Scutellariae radix), Yinchen (Herba Artemisiae Scopariae), Guanghuoxiang (Pogostemonis herba), Roudoukou (Semen myristicae) and Qinghao (Artemisiae annuae herba). A total of 293 active ingredients were screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, and the key ingredients were quercetin, kaempferol, isorhamnetin, stigmasterol, beta-sitosterol, and luteolin. Yin-Chai-Xiao-Du decoction has 138 COVID-19-related targets, and the key targets were mitogen-activated protein kinase 3, interleukin-6, tumor necrosis factor, vascular endothelial growth factor A, and CC motif ligand 2. Kyoto Encyclopedia of Genes and Genomes analysis revealed 120 enriched gene pathways, and the key pathways were signaling by interleukins, immune system, cytokine signaling in the immune system, and the signaling pathways of interleukin-17, tumor necrosis factor, and relaxin.

Conclusion:

The core herbs of Yin-Chai-Xiao-Du decoction are Jinyinhua (Lonicerae japonicae flos), Lianqiao (Forsythia suspensa), Chaihu (Bupleuri radix), Huangqin (Scutellariae radix), Yinchen (Herba Artemisiae Scopariae), Guanghuoxiang (Pogostemonis herba), Roudoukou (Semen myristicae) and Qinghao (Artemisiae annuae herba). The key ingredients are quercetin, kaempferol, isorhamnetin, stigmasterol, and beta-sitosterol;the critical targets are luteolin, interleukin-6, mitogen-activated protein kinase 3, tumor necrosis factor, and CC motif ligand 2;and the core signaling pathways are those mediated by interleukin-17, tumor necrosis factor, and relaxin.
Full text: Available Collection: Databases of international organizations Database: Jul Topics: Traditional medicine Language: Isi document delivery no.: ly8vm times cited: 0 cited reference count: 50 yang lu li ning hu hai-bo yin bin zhao guo-jing wang fen-zhan wang xu-hui wang hong-wu lu xue-zhao cui huan-tian national key researzh and development program [2018yfc1704800] Journal: Coronavirus disease 2019 Bupleuri radix Scutellariae radix Artemisiae annuae herba Cytokine Storm Tumor necrosis factor Interleukin-6 kappa-b pathways inflammatory response cytokine storms inhibition activation luteolin relaxin mapk mice Integrative & Complementary Medicine Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: Jul Topics: Traditional medicine Language: Isi document delivery no.: ly8vm times cited: 0 cited reference count: 50 yang lu li ning hu hai-bo yin bin zhao guo-jing wang fen-zhan wang xu-hui wang hong-wu lu xue-zhao cui huan-tian national key researzh and development program [2018yfc1704800] Journal: Coronavirus disease 2019 Bupleuri radix Scutellariae radix Artemisiae annuae herba Cytokine Storm Tumor necrosis factor Interleukin-6 kappa-b pathways inflammatory response cytokine storms inhibition activation luteolin relaxin mapk mice Integrative & Complementary Medicine Document Type: Article