Aptamers, the bivalent agents as probes and therapies for coronavirus infections: A systematic review.
Mol Cell Probes
; 53: 101636, 2020 10.
Article
in English
| MEDLINE | ID: covidwho-621879
ABSTRACT
The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts have led to production of several diagnostic kits that are associated with limitations such as inadequate sensitivity and accuracy. Aptamers as multipotent biological probes could be promising candidates to design sensitive and specific biosensors. Although few studies have introduced specific aptamer types of coronavirus, they may help us select the best approach to obtain specific aptamers for this virus. On the other hand, some of already-introduced aptamers have shown the inhibitory effects on coronavirus that could be applied as therapeutics. The present study has provided a systematic overview on use of aptamer-based biosensors and drugs to diagnose and treat coronavirus.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Biosensing Techniques
/
Coronavirus Infections
/
Aptamers, Nucleotide
Type of study:
Diagnostic study
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal:
Mol Cell Probes
Journal subject:
Molecular Biology
/
Biotechnology
Year:
2020
Document Type:
Article
Affiliation country:
J.mcp.2020.101636
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