COVID-19 and the Chemical Senses: Supporting Players Take Center Stage.
Neuron
; 107(2): 219-233, 2020 07 22.
Article
in English
| MEDLINE | ID: covidwho-623119
ABSTRACT
The main neurological manifestation of COVID-19 is loss of smell or taste. The high incidence of smell loss without significant rhinorrhea or nasal congestion suggests that SARS-CoV-2 targets the chemical senses through mechanisms distinct from those used by endemic coronaviruses or other common cold-causing agents. Here we review recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception. Given our limited understanding of SARS-CoV-2 pathogenesis, we propose future experiments to elucidate disease mechanisms and highlight the relevance of this ongoing work to understanding how the virus might alter brain function more broadly.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Smell
/
Taste
/
Taste Disorders
/
Coronavirus Infections
/
Betacoronavirus
/
Olfaction Disorders
Type of study:
Observational study
Limits:
Animals
/
Humans
Language:
English
Journal:
Neuron
Journal subject:
Neurology
Year:
2020
Document Type:
Article
Affiliation country:
J.neuron.2020.06.032
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