COVID-19 meets Cystic Fibrosis: for better or worse?
Genes Immun
; 21(4): 260-262, 2020 08.
Article
in English
| MEDLINE | ID: covidwho-623318
ABSTRACT
Cystic fibrosis (CF) is one of the most common autosomal recessive life-limiting conditions affecting Caucasians. The resulting defect in the cystic fibrosis transmembrane conductance regulator protein (CFTR) results in defective chloride and bicarbonate secretion, as well as dysregulation of epithelial sodium channels (ENaC). These changes bring about defective mucociliary clearance, reduced airway surface liquid and an exaggerated proinflammatory response driven, in part, by infection. In this short article we explore the overlap in the pathophysiology of CF and COVID-19 infection and discuss how understanding the interaction between both diseases may shed light on future treatments.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Cystic Fibrosis
Topics:
Long Covid
Limits:
Animals
/
Humans
Language:
English
Journal:
Genes Immun
Journal subject:
Allergy and Immunology
/
Molecular Biology
Year:
2020
Document Type:
Article
Affiliation country:
S41435-020-0103-y
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