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COVID-19 meets Cystic Fibrosis: for better or worse?
Peckham, Daniel; McDermott, Michael F; Savic, Sinisa; Mehta, Anil.
  • Peckham D; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK. d.g.peckham@leeds.ac.uk.
  • McDermott MF; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
  • Savic S; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
  • Mehta A; Division of Medical Sciences, University of Dundee, Dundee, UK.
Genes Immun ; 21(4): 260-262, 2020 08.
Article in English | MEDLINE | ID: covidwho-623318
ABSTRACT
Cystic fibrosis (CF) is one of the most common autosomal recessive life-limiting conditions affecting Caucasians. The resulting defect in the cystic fibrosis transmembrane conductance regulator protein (CFTR) results in defective chloride and bicarbonate secretion, as well as dysregulation of epithelial sodium channels (ENaC). These changes bring about defective mucociliary clearance, reduced airway surface liquid and an exaggerated proinflammatory response driven, in part, by infection. In this short article we explore the overlap in the pathophysiology of CF and COVID-19 infection and discuss how understanding the interaction between both diseases may shed light on future treatments.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Cystic Fibrosis Topics: Long Covid Limits: Animals / Humans Language: English Journal: Genes Immun Journal subject: Allergy and Immunology / Molecular Biology Year: 2020 Document Type: Article Affiliation country: S41435-020-0103-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Cystic Fibrosis Topics: Long Covid Limits: Animals / Humans Language: English Journal: Genes Immun Journal subject: Allergy and Immunology / Molecular Biology Year: 2020 Document Type: Article Affiliation country: S41435-020-0103-y