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Cytokine Storms: Understanding COVID-19.
Mangalmurti, Nilam; Hunter, Christopher A.
  • Mangalmurti N; Perelman School of Medicine, University of Pennsylvania, Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA 19104, USA.
  • Hunter CA; School of Veterinary Medicine, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA. Electronic address: chunter@vet.upenn.edu.
Immunity ; 53(1): 19-25, 2020 07 14.
Article in English | MEDLINE | ID: covidwho-623797
ABSTRACT
The elevated circulating levels of cytokines associated with a variety of infectious and immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the protective functions of cytokines in "ideal" responses; the multi-factorial origins that can drive these responses to become pathological; and how this ultimately leads to vascular damage, immunopathology, and worsening clinical outcomes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cytokines / Coronavirus Infections / Betacoronavirus / Cytokine Release Syndrome Type of study: Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Immunity Journal subject: Allergy and Immunology Year: 2020 Document Type: Article Affiliation country: J.immuni.2020.06.017

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cytokines / Coronavirus Infections / Betacoronavirus / Cytokine Release Syndrome Type of study: Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Immunity Journal subject: Allergy and Immunology Year: 2020 Document Type: Article Affiliation country: J.immuni.2020.06.017