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The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
Coutard, B; Valle, C; de Lamballerie, X; Canard, B; Seidah, N G; Decroly, E.
  • Coutard B; Unité des Virus Émergents (UVE: Aix-Marseille Univ - IRD 190 - Inserm 1207 - IHU Méditerranée Infection), Marseille, France.
  • Valle C; Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France.
  • de Lamballerie X; Unité des Virus Émergents (UVE: Aix-Marseille Univ - IRD 190 - Inserm 1207 - IHU Méditerranée Infection), Marseille, France.
  • Canard B; Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France.
  • Seidah NG; Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM, Affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W1R7, Canada.
  • Decroly E; Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France. Electronic address: etienne.decroly@afmb.univ-mrs.fr.
Antiviral Res ; 176: 104742, 2020 04.
Article in English | MEDLINE | ID: covidwho-624
ABSTRACT
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Furin / Spike Glycoprotein, Coronavirus / Betacoronavirus Language: English Journal: Antiviral Res Year: 2020 Document Type: Article Affiliation country: J.antiviral.2020.104742

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Furin / Spike Glycoprotein, Coronavirus / Betacoronavirus Language: English Journal: Antiviral Res Year: 2020 Document Type: Article Affiliation country: J.antiviral.2020.104742