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Evolution of Altered Sense of Smell or Taste in Patients With Mildly Symptomatic COVID-19.
Boscolo-Rizzo, Paolo; Borsetto, Daniele; Fabbris, Cristoforo; Spinato, Giacomo; Frezza, Daniele; Menegaldo, Anna; Mularoni, Francesca; Gaudioso, Piergiorgio; Cazzador, Diego; Marciani, Silvia; Frasconi, Samuele; Ferraro, Maria; Berro, Cecilia; Varago, Chiara; Nicolai, Piero; Tirelli, Giancarlo; Da Mosto, Maria Cristina; Obholzer, Rupert; Rigoli, Roberto; Polesel, Jerry; Hopkins, Claire.
  • Boscolo-Rizzo P; Section of Otorhinolaryngology, University of Padova, Treviso, Italy.
  • Borsetto D; Guy's and St Thomas' Hospitals, London, United Kingdom.
  • Fabbris C; Section of Otorhinolaryngology, University of Padova, Treviso, Italy.
  • Spinato G; Section of Otorhinolaryngology, University of Padova, Treviso, Italy.
  • Frezza D; Section of Otorhinolaryngology, University of Padova, Treviso, Italy.
  • Menegaldo A; Section of Otorhinolaryngology, University of Padova, Treviso, Italy.
  • Mularoni F; Section of Otorhinolaryngology, University of Padova, Treviso, Italy.
  • Gaudioso P; Section of Otorhinolaryngology, University of Padova, Treviso, Italy.
  • Cazzador D; Section of Otorhinolaryngology, University of Padova, Padova, Italy.
  • Marciani S; Section of Otorhinolaryngology, University of Padova, Treviso, Italy.
  • Frasconi S; Section of Otorhinolaryngology, University of Padova, Padova, Italy.
  • Ferraro M; Section of Otorhinolaryngology, University of Padova, Treviso, Italy.
  • Berro C; Section of Otorhinolaryngology, University of Padova, Treviso, Italy.
  • Varago C; Section of Otorhinolaryngology, University of Padova, Treviso, Italy.
  • Nicolai P; Section of Otorhinolaryngology, University of Padova, Padova, Italy.
  • Tirelli G; Head and Neck Department, Cattinara Hospital, University of Trieste, Trieste, Italy.
  • Da Mosto MC; Section of Otorhinolaryngology, University of Padova, Treviso, Italy.
  • Obholzer R; Guy's and St Thomas' Hospitals, London, United Kingdom.
  • Rigoli R; Department of Clinical Pathology, AULSS 2 - Marca Trevigiana, Treviso, Italy.
  • Polesel J; Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
  • Hopkins C; Guy's and St Thomas' Hospitals, London, United Kingdom.
JAMA Otolaryngol Head Neck Surg ; 146(8): 729-732, 2020 08 01.
Article in English | MEDLINE | ID: covidwho-624510
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
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PROCESS_OF
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Patients
2. Esthesia PROCESS_OF Patients
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Esthesia
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PROCESS_OF
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Patients
3. COVID-19 AFFECTS Esthesia
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COVID-19
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AFFECTS
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Esthesia
4. Disease INTERACTS_WITH 2019 novel coronavirus
Subject
Disease
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INTERACTS_WITH
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2019 novel coronavirus
5. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Subject
Severe Acute Respiratory Syndrome
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PROCESS_OF
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Patients
6. COVID-19 PROCESS_OF Patients
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COVID-19
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PROCESS_OF
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Patients
7. Esthesia PROCESS_OF Patients
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Esthesia
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PROCESS_OF
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Patients
8. COVID-19 AFFECTS Esthesia
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COVID-19
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AFFECTS
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Esthesia
9. Disease INTERACTS_WITH 2019 novel coronavirus
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Disease
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2019 novel coronavirus
10. Severe Acute Respiratory Syndrome PROCESS_OF Patients
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ABSTRACT
Importance An altered sense of smell and taste has been reported to be associated with coronavirus disease 2019 (COVID-19). To understand the evolution of these symptoms during the course of the disease is important to identify patients with persistent loss of smell or taste and estimate the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the burden of olfactory and gustative dysfunctions.

Objective:

To evaluate the evolution of the loss of sense of smell and taste in a case series of mildly symptomatic patients with SARS-CoV-2 infection. Design, Setting, and

Participants:

This cross-sectional survey-based study included 202 mildly symptomatic adults (≥18 years) consecutively assessed at Treviso Regional Hospital, Italy, between March 19 and March 22, 2020, who tested positive for SARS-CoV-2 RNA by polymerase chain reaction on nasopharyngeal and throat swabs. Main Outcomes and

Measures:

Prevalence of altered sense of smell and taste at follow-up and their variation from baseline.

Results:

Of 202 patients completing the survey at baseline, 187 (92.6%) also completed the follow-up survey (103 [55.1%] women; median age, 56 years). The evaluation of the evolution of altered sense of smell or taste in the 113 patients reporting sudden onset of these symptoms at baseline showed that 55 patients (48.7%; 95% CI, 39.2-58.3) reported complete resolution of smell or taste impairment, 46 (40.7%; 95% CI, 31.6-50.4) reported an improvement in the severity, and only 12 (10.6%; 95% CI, 5.6-17.8) reported the symptom was unchanged or worse. Persistent loss of smell or taste was not associated with persistent SARS-CoV-2 infection. Conclusions and Relevance At 4 weeks from the onset, 89% of the SARS-CoV-2-positive mildly symptomatic patients who had had a sudden onset of altered sense of smell or taste experienced a complete resolution or improvement of these symptoms. Persistent loss of smell or taste was not associated with persistent SARS-CoV-2 infection.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Taste Disorders / COVID-19 / Olfaction Disorders Type of study: Diagnostic study / Observational study / Prevalence study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: JAMA Otolaryngol Head Neck Surg Year: 2020 Document Type: Article Affiliation country: Jamaoto.2020.1379

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Taste Disorders / COVID-19 / Olfaction Disorders Type of study: Diagnostic study / Observational study / Prevalence study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: JAMA Otolaryngol Head Neck Surg Year: 2020 Document Type: Article Affiliation country: Jamaoto.2020.1379