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Is the presence of lung injury in COVID-19 an independent risk factor for secondary lung cancer?
Tao, Shao-Lin; Wang, Xue-Mei; Feng, Yong-Geng; Kang, Po-Ming; Li, Qing-Yuan; Sun, Tian-Yu; Tan, Qun-You; Deng, Bo.
  • Tao SL; Department of Thoracic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, PR China.
  • Wang XM; Department of Pediatrics, Armed Corps Police Hospital of Chongqing, Chongqing 400061, PR China.
  • Feng YG; Department of Thoracic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, PR China.
  • Kang PM; Department of Thoracic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, PR China.
  • Li QY; Department of Thoracic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, PR China.
  • Sun TY; Department of Thoracic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, PR China.
  • Tan QY; Department of Thoracic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, PR China.
  • Deng B; Department of Thoracic Surgery, Daping Hospital, Army Medical University, Chongqing 400042, PR China. Electronic address: dengbo@tmmu.edu.cn.
Med Hypotheses ; 143: 110074, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-625625
ABSTRACT
The morbidity and mortality of lung cancer are increasing. The Corona Virus Disease 2019 (COVID-19) is caused by novel coronavirus 2019-nCoV-2, leading to subsequent pulmonary interstitial fibrosis with chronic inflammatory changes, e.g., inflammatory factors repeatedly continuously stimulating and attacking the alveolar epithelial cells. Meanwhile, 2019-nCoV-2 can activate PI3K/Akt and ERK signaling pathways, which can play the double roles as both anti-inflammatory and carcinogenic factors. Moreover, hypoxemia may be developed, resulting in the up-regulation of HIF-1 α expression, which can be involved in the occurrence, angiogenesis, invasion and metastasis of lung cancer. Additionally, the immune system in 2019-nCoV-2 infected cases can be suppressed to cause tumor immune evasion. Therefore, we speculate that COVID-19 may be a risk factor of secondary lung cancer.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Lung Injury / Betacoronavirus / Lung Neoplasms Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Lung Injury / Betacoronavirus / Lung Neoplasms Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article