Retrospective Analysis of 61 Cases of Children Died of Viral Pneumonia.
Fa Yi Xue Za Zhi
; 36(2): 164-168, 2020 Apr.
Article
in English, Chinese
| MEDLINE | ID: covidwho-627698
ABSTRACT
ABSTRACT Objective To retrospectively analyze the forensic pathological postmortem examination and clinical data of children who died of viral pneumonia in identification of cause of death cases and to discuss the clinical characteristics and pathological features of viral pneumonia in children, in order to provide reference to pathological diagnosis of viral pneumonia in children caused by 2019 novel coronavirus ï¼2019-nCoVï¼ infection. Methods Postmortem examination data from 61 cases of children whose causes of death were identified as viral pneumonia in recent years were collected from the Center of Forensic Identification, Southern Medical University. The gender, age, clinical symptoms and pathological features were comparatively analyzed. Results Among the 61 cases of children who died of viral pneumonia, most were within 2 years old ï¼83.61%ï¼, and a large proportion died within 2 weeks after the onset of the disease ï¼91.80%ï¼. Gross changes in postmortem examination included respiratory mucosal hyperemia, pleural effusion, pulmonary swelling, variegated pulmonary pleura and serosa, as well as focal pulmonary hemorrhage and pulmonary edema. A large proportion of sick children had enlarged mesenteric lymph nodes ï¼83.61%ï¼ and thymic dysplasia ï¼21.31%ï¼. Histopathological changes included edema of alveoli and interstitial substance, pneumorrhagiaï¼shedding of alveolar epithelial cells, serous and ï¼orï¼ fibrous exudation in the alveoli, formation of viral inclusions, formation of transparent membranes, infiltration of inflammatory cells that mainly consisted of macrophages and lymphocytes in interstitial substance and alveoli. Viral infections often affected the heart and gastrointestinal tract. Conclusion The clinical symptoms of children with viral pneumonia are difficult to notice, and because the immune systems of children are not fully developed and they have poor immunity, they can easily become severely ill and even die. Analyzing the forensic autopsies and the histopathological characteristics could provide reference for pathological diagnosis of viral pneumonia.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Pandemics
/
Betacoronavirus
Type of study:
Observational study
/
Prognostic study
Limits:
Child
/
Child, preschool
/
Humans
Language:
English
/
Chinese
Journal:
Fa Yi Xue Za Zhi
Journal subject:
Jurisprudence
Year:
2020
Document Type:
Article
Affiliation country:
J.issn.1004-5619.2020.02.003
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