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A retrospective study of risk factors for severe acute respiratory syndrome coronavirus 2 infections in hospitalized adult patients.
Yao, Qingchun; Wang, Peng; Wang, Xingguang; Qie, Guoqiang; Meng, Mei; Tong, Xiwen; Bai, Xue; Ding, Min; Liu, Weiming; Liu, Keke; Chu, Yufeng.
  • Yao Q; Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
  • Wang P; Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
  • Wang X; Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China
  • Qie G; Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
  • Meng M; Department of Critical Care Medicine, Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China
  • Tong X; Department of Cardio­Thoracic Surgery, Huanggang Central Hospital, Huanggang, China
  • Bai X; Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
  • Ding M; Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
  • Liu W; Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
  • Liu K; Shandong Academy of Clinical Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China
  • Chu Y; Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China. chunancy@163.com
Pol Arch Intern Med ; 130(5): 390-399, 2020 05 29.
Article in English | MEDLINE | ID: covidwho-627704
ABSTRACT

INTRODUCTION:

Coronavirus disease 2019 (COVID­19) caused by severe acute respiratory syndrome coronavirus 2 (SARS­CoV­2) infection spread worldwide.

OBJECTIVES:

The aim of the study was to identify the clinical characteristics and risk factors associated with severe incidence of SARS ­CoV­2 infection. PATIENTS AND

METHODS:

All adult patients (median [IQR] age, 52 [37-58] years) consecutively admitted to the Dabieshan Medical Center from January 30, 2020 to February 11, 2020 were collected and reviewed. Only patients diagnosed with COVID­19  according to the World Health Organization interim guidance were included in this retrospective cohort study.

RESULTS:

A total of 108 patients with COVID­19 were retrospectively analyzed. Twenty­five patients (23.1%) developed severe disease, and of those 12 patients (48%) died. Advanced age, comorbidities (most commonly hypertension), higher blood leukocyte count, neutrophil count, higher C­reactive protein level, D­dimer level, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and Sequential Organ Failure Assessment (SOFA) score were associated with greater risk of COVID­19, and so were lower lymphocyte count and albumin level. Multivariable regress ion showed increasing odds of severe COVID­19 associated with higher SOFA score (odds ratio [OR], 2.45; 95% CI, 1.302-4.608; P = 0.005), and lymphocyte count less than 0.8 × 109/l (OR, 9.017; 95% CI, 2.808-28.857; P <0.001) on admission. Higher SOFA score (OR, 2.402; 95% CI, 1.313-4.395; P = 0.004) on admission was identified as risk factor for in­hospital death.

CONCLUSIONS:

Lymphocytopenia and a higher SOFA score on admission could help clinicians to identify patients at high risk for developing severe COVID­19. More related studies are needed in the future.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Severity of Illness Index / Coronavirus Infections / Betacoronavirus / Multiple Organ Failure Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Pol Arch Intern Med Year: 2020 Document Type: Article Affiliation country: Pamw.15312

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Severity of Illness Index / Coronavirus Infections / Betacoronavirus / Multiple Organ Failure Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Pol Arch Intern Med Year: 2020 Document Type: Article Affiliation country: Pamw.15312