The SARS-CoV-2 main protease as drug target.
Bioorg Med Chem Lett
; 30(17): 127377, 2020 09 01.
Article
in English
| MEDLINE | ID: covidwho-627941
ABSTRACT
The unprecedented pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is threatening global health. The virus emerged in late 2019 and can cause a severe disease associated with significant mortality. Several vaccine development and drug discovery campaigns are underway. The SARS-CoV-2 main protease is considered a promising drug target, as it is dissimilar to human proteases. Sequence and structure of the main protease are closely related to those from other betacoronaviruses, facilitating drug discovery attempts based on previous lead compounds. Covalently binding peptidomimetics and small molecules are investigated. Various compounds show antiviral activity in infected human cells.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Cysteine Proteinase Inhibitors
/
Viral Nonstructural Proteins
/
Betacoronavirus
Topics:
Vaccines
Limits:
Animals
/
Humans
Language:
English
Journal:
Bioorg Med Chem Lett
Journal subject:
Biochemistry
/
Chemistry
Year:
2020
Document Type:
Article
Affiliation country:
J.bmcl.2020.127377
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