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The accuracy of haemoglobin A1c as a screening and diagnostic test for gestational diabetes: a systematic review and meta-analysis of test accuracy studies.
Amaefule, Chiamaka Esther; Sasitharan, Archana; Kalra, Princee; Iliodromoti, Stamatina; Huda, Mohammed S B; Rogozinska, Ewelina; Zamora, Javier; Thangaratinam, Shakila.
  • Amaefule CE; Barts Research Centre for Women's Health, Institute of Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Sasitharan A; Barts Research Centre for Women's Health, Institute of Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Kalra P; Barts Research Centre for Women's Health, Institute of Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Iliodromoti S; Barts Research Centre for Women's Health, Institute of Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Huda MSB; Department of Diabetes & Metabolism, Barts Health NHS Trust, Royal London Hospital, London, UK.
  • Rogozinska E; Barts Research Centre for Women's Health, Institute of Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Zamora J; Barts Research Centre for Women's Health, Institute of Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Thangaratinam S; Clinical Biostatistics Unit, Hospital Ramon y Cajal (IRYCIS) and CIBER Epidemiology and Public Health, Madrid, Spain.
Curr Opin Obstet Gynecol ; 32(5): 322-334, 2020 10.
Article in English | MEDLINE | ID: covidwho-629087
Semantic information from SemMedBD (by NLM)
1. Pregnancy Complications COEXISTS_WITH Gestational Diabetes
Subject
Pregnancy Complications
Predicate
COEXISTS_WITH
Object
Gestational Diabetes
2. Gestational Diabetes PROCESS_OF Woman
Subject
Gestational Diabetes
Predicate
PROCESS_OF
Object
Woman
3. Pregnancy Complications COEXISTS_WITH Gestational Diabetes
Subject
Pregnancy Complications
Predicate
COEXISTS_WITH
Object
Gestational Diabetes
4. Gestational Diabetes PROCESS_OF Woman
Subject
Gestational Diabetes
Predicate
PROCESS_OF
Object
Woman
ABSTRACT
PURPOSE OF REVIEW Gestational diabetes mellitus (GDM) is associated with adverse pregnancy complications. Accurate screening and diagnosis of gestational diabetes are critical to treatment, and in a pandemic scenario like coronavirus disease 2019 needing a simple test that minimises prolonged hospital stay. We undertook a meta-analysis on the screening and diagnostic accuracy of the haemoglobin A1c (HbA1c) test in women with and without risk factors for gestational diabetes. RECENT

FINDINGS:

Unlike the oral glucose tolerance test, the HbA1c test is simple, quick and more acceptable. There is a growing body of evidence on the accuracy of HbA1c as a screening and diagnostic test for GDM. We searched Medline, Embase and Cochrane Library and selected relevant studies. Accuracy data for different thresholds within the final 23 included studies (16 921 women) were pooled using a multiple thresholds model. Summary accuracy indices were estimated by selecting an optimal threshold that optimises either sensitivity or specificity according to different scenarios.

SUMMARY:

HbA1c is more useful as a specific test at a cut-off of 5.7% (39 mmol/mol) with a false positive rate of 10%, but should be supplemented by a more sensitive test to detect women with GDM.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Glycated Hemoglobin A / Diabetes, Gestational Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Reviews / Risk factors / Screening study / Systematic review Limits: Female / Humans / Pregnancy Language: English Journal: Curr Opin Obstet Gynecol Journal subject: Gynecology / Obstetrics Year: 2020 Document Type: Article Affiliation country: GCO.0000000000000648

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Glycated Hemoglobin A / Diabetes, Gestational Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Reviews / Risk factors / Screening study / Systematic review Limits: Female / Humans / Pregnancy Language: English Journal: Curr Opin Obstet Gynecol Journal subject: Gynecology / Obstetrics Year: 2020 Document Type: Article Affiliation country: GCO.0000000000000648