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Clinical Manifestation and Neonatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China.
Xu, Shuang; Shao, Fei; Bao, Banghe; Ma, Xuedi; Xu, Zhouming; You, Jiwen; Zhao, Peng; Liu, Yuwei; Ng, Michael; Cui, Hao; Yu, Changxiao; Zhang, Qing; Li, Dandan; Tang, Ziren; Sun, Peng.
  • Xu S; Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Shao F; Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital, Beijing, China.
  • Bao B; Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
  • Ma X; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xu Z; AI Research Division, A.I. Phoenix Technology Co., Ltd, Hong Kong, China.
  • You J; AI Research Division, A.I. Phoenix Technology Co., Ltd, Hong Kong, China.
  • Zhao P; Research Division for Mathematical and Statistical Science, University of Hong Kong, Hong Kong, China.
  • Liu Y; AI Research Division, A.I. Phoenix Technology Co., Ltd, Hong Kong, China.
  • Ng M; AI Research Division, A.I. Phoenix Technology Co., Ltd, Hong Kong, China.
  • Cui H; AI Research Division, A.I. Phoenix Technology Co., Ltd, Hong Kong, China.
  • Yu C; Research Division for Mathematical and Statistical Science, University of Hong Kong, Hong Kong, China.
  • Zhang Q; Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
  • Li D; Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
  • Tang Z; Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Sun P; Sanquan College Of Xinxiang Medical University, Xinxiang, China.
Open Forum Infect Dis ; 7(7): ofaa283, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-846713
ABSTRACT

BACKGROUND:

Clinical manifestation and neonatal outcomes of pregnant women with coronavirus disease 2019 (COVID-19) were unclear in Wuhan, China.

METHODS:

We retrospectively analyzed clinical characteristics of pregnant and nonpregnant women with COVID-19 aged from 20 to 40, admitted between January 15 and March 15, 2020 at Union Hospital, Wuhan, and symptoms of pregnant women with COVID-19 and compared the clinical characteristics and symptoms to historic data previously reported for H1N1.

RESULTS:

Among 64 patients, 34 (53.13%) were pregnant, with higher proportion of exposure history (29.41% vs 6.67%) and more pulmonary infiltration on computed tomography test (50% vs 10%) compared to nonpregnant women. Of pregnant patients, 27 (79.41%) completed pregnancy, 5 (14.71%) had natural delivery, 18 (52.94%) had cesarean section, and 4 (11.76%) had abortion; 5 (14.71%) patients were asymptomatic. All 23 newborns had negative reverse-transcription polymerase chain results, and an average 1-minute Apgar score was 8-9 points. Pregnant and nonpregnant patients show differences in symptoms such as fever, expectoration, and fatigue and on laboratory tests such as neurophils, fibrinogen, D-dimer, and erythrocyte sedimentation rate. Pregnant patients with COVID-19 tend to have more milder symptoms than those with H1N1.

CONCLUSIONS:

Clinical characteristics of pregnant patients with COVID-19 are less serious than nonpregnant. No evidence indicated that pregnant women may have fetal infection through vertical transmission of COVID-19. Pregnant patients with H1N1 had more serious condition than those with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2020 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2020 Document Type: Article Affiliation country: Ofid