A comparison of mortality-related risk factors of COVID-19, SARS, and MERS: A systematic review and meta-analysis.
J Infect
; 81(4): e18-e25, 2020 10.
Article
in English
| MEDLINE | ID: covidwho-629626
ABSTRACT
OBJECTIVE:
Coronavirus Disease 2019 (COVID-19) is a pandemic. This systematic review compares mortality risk factors including clinical, demographic and laboratory features of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The aim is to provide new strategies for COVID-19 prevention and treatment.METHODS:
We performed a systematic review with meta-analysis, using five databases to compare the predictors of death for COVID-19, SARS and MERS. A random-effects model meta-analysis calculated odds ratios (OR) and 95% confidence intervals (95% CI).RESULTS:
845 articles up through 11/4/2020 were retrieved, but only 28 studies were included in this meta-analysis. The results showed that males had a higher likelihood of death than females (ORâ¯=â¯1.82, 95% CI 1.56-2.13). Age (ORâ¯=â¯7.86, 95% CI 5.46-11.29), diabetes comorbidity (ORâ¯=â¯3.73, 95% CI 2.35-5.90), chronic lung disease (ORâ¯=â¯3.43, 95% CI 1.80-6.52) and hypertension (ORâ¯=â¯3.38, 95% CI 2.45-4.67) were the mortality risk factors. The laboratory indicators lactic dehydrogenase (ORâ¯=â¯37.52, 95% CI 24.68-57.03), C-reactive protein (ORâ¯=â¯12.11, 95% CI 5.24-27.98), and neutrophils (ORâ¯=â¯17.56, 95% CI 10.67-28.90) had stronger correlations with COVID-19 mortality than with SARS or MERS mortality. Consolidation and ground-glass opacity imaging features were similar among COVID-19, SARS, and MERS patients.CONCLUSIONS:
COVID-19's mortality factors are similar to those of SARS and MERS. Age and laboratory indicators could be effective predictors of COVID-19 mortality outcomes.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Risk Factors
/
Coronavirus Infections
/
Severe Acute Respiratory Syndrome
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J Infect
Year:
2020
Document Type:
Article
Affiliation country:
J.jinf.2020.07.002
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