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Effects of tobacco cigarettes, e-cigarettes, and waterpipe smoking on endothelial function and clinical outcomes.
Münzel, Thomas; Hahad, Omar; Kuntic, Marin; Keaney, John F; Deanfield, John E; Daiber, Andreas.
  • Münzel T; Center for Cardiology-Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
  • Hahad O; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Langenbeckstraße 1, 55131 Mainz, Germany.
  • Kuntic M; Center for Cardiology-Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
  • Keaney JF; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Langenbeckstraße 1, 55131 Mainz, Germany.
  • Deanfield JE; Center for Cardiology-Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany.
  • Daiber A; Division of Cardiovascular Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
Eur Heart J ; 41(41): 4057-4070, 2020 11 01.
Article in English | MEDLINE | ID: covidwho-630381
ABSTRACT
Tobacco smoking is a leading cause of non-communicable disease globally and is a major risk factor for cardiovascular disease (CVD) and lung disease. Importantly, recent data by the World Health Organizations (WHO) indicate that in the last two decades global tobacco use has significantly dropped, which was largely driven by decreased numbers of female smokers. Despite such advances, the use of e-cigarettes and waterpipes (shisha, hookah, narghile) is an emerging trend, especially among younger generations. There is growing body of evidence that e-cigarettes are not a harm-free alternative to tobacco cigarettes and there is considerable debate as to whether e-cigarettes are saving smokers or generating new addicts. Here, we provide an updated overview of the impact of tobacco/waterpipe (shisha) smoking and e-cigarette vaping on endothelial function, a biomarker for early, subclinical, atherosclerosis from human and animal studies. Also their emerging adverse effects on the proteome, transcriptome, epigenome, microbiome, and the circadian clock are summarized. We briefly discuss heat-not-burn tobacco products and their cardiovascular health effects. We discuss the impact of the toxic constituents of these products on endothelial function and subsequent CVD and we also provide an update on current recommendations, regulation and advertising with focus on the USA and Europe. As outlined by the WHO, tobacco cigarette, waterpipe, and e-cigarette smoking/vaping may contribute to an increased burden of symptoms due to coronavirus disease 2019 (COVID-19) and to severe health consequences.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelium, Vascular / Cardiovascular Diseases / Tobacco Products / Electronic Nicotine Delivery Systems / Water Pipe Smoking Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Eur Heart J Year: 2020 Document Type: Article Affiliation country: Eurheartj

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelium, Vascular / Cardiovascular Diseases / Tobacco Products / Electronic Nicotine Delivery Systems / Water Pipe Smoking Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Eur Heart J Year: 2020 Document Type: Article Affiliation country: Eurheartj