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Incretin-Based Therapies Role in COVID-19 Era: Evolving Insights.
Stoian, Anca Pantea; Papanas, Nikolaos; Prazny, Martin; Rizvi, Ali A; Rizzo, Manfredi.
  • Stoian AP; Diabetes, Nutrition and Metabolic Diseases Department, 87267"Carol Davila" University of Medicine, Bucharest, Romania.
  • Papanas N; Diabetes Center, Second Department of Internal Medicine, 387479Democritus University of Thrace, University Hospital of Alexandroupolis, Greece.
  • Prazny M; Third Department of Internal Medicine, First Faculty of Medicine, 37740Charles University, Prague, Czech Republic.
  • Rizvi AA; Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, 1371Emory University, Atlanta, GA, USA.
  • Rizzo M; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of South Carolina, Columbia, SC, USA.
J Cardiovasc Pharmacol Ther ; 25(6): 494-496, 2020 11.
Article in English | MEDLINE | ID: covidwho-630976
Semantic information from SemMedBD (by NLM)
1. Therapeutic procedure USES Incretins
Subject
Therapeutic procedure
Predicate
USES
Object
Incretins
2. Incretins COEXISTS_WITH estrogen receptor alph
Subject
Incretins
Predicate
COEXISTS_WITH
Object
estrogen receptor alph
3. Pandemics CAUSES Disease
Subject
Pandemics
Predicate
CAUSES
Object
Disease
4. Dipeptidyl-Peptidase IV PART_OF Homo sapiens
Subject
Dipeptidyl-Peptidase IV
Predicate
PART_OF
Object
Homo sapiens
5. Dipeptidyl-Peptidase IV INTERACTS_WITH M Protei
Subject
Dipeptidyl-Peptidase IV
Predicate
INTERACTS_WITH
Object
M Protei
6. M Protei PART_OF C5203676
Subject
M Protei
Predicate
PART_OF
Object
C5203676
7. Incretins TREATS Diabetes Mellitu
Subject
Incretins
Predicate
TREATS
Object
Diabetes Mellitu
8. Diabetes Mellitu PROCESS_OF C0030705
Subject
Diabetes Mellitu
Predicate
PROCESS_OF
Object
C0030705
9. Incretins TREATS Patients
Subject
Incretins
Predicate
TREATS
Object
Patients
10. COVID-19 COEXISTS_WITH Diabetes
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
Diabetes
11. Treatment Protocols TREATS Diabetes Mellitu
Subject
Treatment Protocols
Predicate
TREATS
Object
Diabetes Mellitu
12. Treatment Protocols USES Antidiabetics
Subject
Treatment Protocols
Predicate
USES
Object
Antidiabetics
13. Treatment Protocols TREATS Patients
Subject
Treatment Protocols
Predicate
TREATS
Object
Patients
14. Therapeutic procedure USES Incretins
Subject
Therapeutic procedure
Predicate
USES
Object
Incretins
15. Incretins COEXISTS_WITH estrogen receptor alpha, human
Subject
Incretins
Predicate
COEXISTS_WITH
Object
estrogen receptor alpha, human
16. Pandemics CAUSES Disease
Subject
Pandemics
Predicate
CAUSES
Object
Disease
17. Dipeptidyl-Peptidase IV PART_OF Homo sapiens
Subject
Dipeptidyl-Peptidase IV
Predicate
PART_OF
Object
Homo sapiens
18. Dipeptidyl-Peptidase IV INTERACTS_WITH M Protein, multiple myeloma
Subject
Dipeptidyl-Peptidase IV
Predicate
INTERACTS_WITH
Object
M Protein, multiple myeloma
19. M Protein, multiple myeloma PART_OF 2019 novel coronavirus
Subject
M Protein, multiple myeloma
Predicate
PART_OF
Object
2019 novel coronavirus
20. Incretins TREATS Diabetes Mellitus, Non-Insulin-Dependent
Subject
Incretins
Predicate
TREATS
Object
Diabetes Mellitus, Non-Insulin-Dependent
21. Diabetes Mellitus, Non-Insulin-Dependent PROCESS_OF Patients
Subject
Diabetes Mellitus, Non-Insulin-Dependent
Predicate
PROCESS_OF
Object
Patients
22. Incretins TREATS Patients
Subject
Incretins
Predicate
TREATS
Object
Patients
23. COVID-19 COEXISTS_WITH Diabetes
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
Diabetes
24. Treatment Protocols TREATS Diabetes Mellitus, Non-Insulin-Dependent
Subject
Treatment Protocols
Predicate
TREATS
Object
Diabetes Mellitus, Non-Insulin-Dependent
25. Treatment Protocols USES Antidiabetics
Subject
Treatment Protocols
Predicate
USES
Object
Antidiabetics
26. Treatment Protocols TREATS Patients
Subject
Treatment Protocols
Predicate
TREATS
Object
Patients
ABSTRACT
The current coronavirus disease 2019 (COVID-19) pandemic has led the scientific community to breach new frontiers in the understanding of human physiology and disease pathogenesis. It has been hypothesized that the human dipeptidyl peptidase 4 (DPP4) enzyme receptor may be a functional target for the spike proteins of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Since DPP4-inhibitors are currently used for the treatment of patients with type-2 diabetes (T2DM), there is currently high interest in the possibility that these agents, or incretin-based therapies (IBTs) in general, may be of benefit against the new coronavirus infection. Diabetes is associated with increased COVID-19 severity and mortality, and accumulating evidence suggests that IBTs may favorably alter the clinical course of SARS-CoV-2 infection due to their inherent mechanisms of action. Further research into prognostic variables associated with various antidiabetic treatment regimens, and in particular the IBT, in patients with T2DM affected by the COVID-19 pandemic is therefore warranted.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Diabetes Mellitus, Type 2 / Dipeptidyl-Peptidase IV Inhibitors / Incretins Type of study: Prognostic study Limits: Humans Language: English Journal: J Cardiovasc Pharmacol Ther Journal subject: Vascular Diseases / Cardiology / Pharmacology Year: 2020 Document Type: Article Affiliation country: 1074248420937868

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Diabetes Mellitus, Type 2 / Dipeptidyl-Peptidase IV Inhibitors / Incretins Type of study: Prognostic study Limits: Humans Language: English Journal: J Cardiovasc Pharmacol Ther Journal subject: Vascular Diseases / Cardiology / Pharmacology Year: 2020 Document Type: Article Affiliation country: 1074248420937868