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Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia.
De Biasi, Sara; Meschiari, Marianna; Gibellini, Lara; Bellinazzi, Caterina; Borella, Rebecca; Fidanza, Lucia; Gozzi, Licia; Iannone, Anna; Lo Tartaro, Domenico; Mattioli, Marco; Paolini, Annamaria; Menozzi, Marianna; Milic, Jovana; Franceschi, Giacomo; Fantini, Riccardo; Tonelli, Roberto; Sita, Marco; Sarti, Mario; Trenti, Tommaso; Brugioni, Lucio; Cicchetti, Luca; Facchinetti, Fabio; Pietrangelo, Antonello; Clini, Enrico; Girardis, Massimo; Guaraldi, Giovanni; Mussini, Cristina; Cossarizza, Andrea.
  • De Biasi S; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125, Modena, Italy.
  • Meschiari M; Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, via del Pozzo 71, 41124, Modena, Italy.
  • Gibellini L; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125, Modena, Italy.
  • Bellinazzi C; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125, Modena, Italy.
  • Borella R; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125, Modena, Italy.
  • Fidanza L; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125, Modena, Italy.
  • Gozzi L; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125, Modena, Italy.
  • Iannone A; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125, Modena, Italy.
  • Lo Tartaro D; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125, Modena, Italy.
  • Mattioli M; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125, Modena, Italy.
  • Paolini A; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125, Modena, Italy.
  • Menozzi M; Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, via del Pozzo 71, 41124, Modena, Italy.
  • Milic J; Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, via del Pozzo 71, 41124, Modena, Italy.
  • Franceschi G; Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, via del Pozzo 71, 41124, Modena, Italy.
  • Fantini R; Respiratory Diseases Unit, AOU Policlinico and University of Modena and Reggio Emilia, via del Pozzo 71, 41124, Modena, Italy.
  • Tonelli R; Respiratory Diseases Unit, AOU Policlinico and University of Modena and Reggio Emilia, via del Pozzo 71, 41124, Modena, Italy.
  • Sita M; Department of Anesthesia and Intensive Care, AOU Policlinico and University of Modena and Reggio Emilia, via del Pozzo 71, 41124, Modena, Italy.
  • Sarti M; Clinical Microbiology Unit, AOU Policlinico, via del Pozzo 71, 41124, Modena, Italy.
  • Trenti T; Clinical Microbiology Unit, AOU Policlinico, via del Pozzo 71, 41124, Modena, Italy.
  • Brugioni L; Emergency Department, MIAC, AOU Policlinico, via del Pozzo 71, 41124, Modena, Italy.
  • Cicchetti L; Labospace, via Apelle 41, 20128, Milano, Italy.
  • Facchinetti F; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125, Modena, Italy.
  • Pietrangelo A; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125, Modena, Italy.
  • Clini E; Respiratory Diseases Unit, AOU Policlinico and University of Modena and Reggio Emilia, via del Pozzo 71, 41124, Modena, Italy.
  • Girardis M; Department of Anesthesia and Intensive Care, AOU Policlinico and University of Modena and Reggio Emilia, via del Pozzo 71, 41124, Modena, Italy.
  • Guaraldi G; Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, via del Pozzo 71, 41124, Modena, Italy.
  • Mussini C; Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, via del Pozzo 71, 41124, Modena, Italy.
  • Cossarizza A; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41125, Modena, Italy. andrea.cossarizza@unimore.it.
Nat Commun ; 11(1): 3434, 2020 07 06.
Article in English | MEDLINE | ID: covidwho-631255
ABSTRACT
The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia are urgently required. Here we show that, compared with healthy controls, COVID-19 patients' T cell compartment displays several alterations involving naïve, central memory, effector memory and terminally differentiated cells, as well as regulatory T cells and PD1+CD57+ exhausted T cells. Significant alterations exist also in several lineage-specifying transcription factors and chemokine receptors. Terminally differentiated T cells from patients proliferate less than those from healthy controls, whereas their mitochondria functionality is similar in CD4+ T cells from both groups. Patients display significant increases of proinflammatory or anti-inflammatory cytokines, including T helper type-1 and type-2 cytokines, chemokines and galectins; their lymphocytes produce more tumor necrosis factor (TNF), interferon-γ, interleukin (IL)-2 and IL-17, with the last observation implying that blocking IL-17 could provide a novel therapeutic strategy for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / CD4-Positive T-Lymphocytes / T-Lymphocyte Subsets / Coronavirus Infections / CD8-Positive T-Lymphocytes / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Country/Region as subject: Europa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-17292-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / CD4-Positive T-Lymphocytes / T-Lymphocyte Subsets / Coronavirus Infections / CD8-Positive T-Lymphocytes / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Country/Region as subject: Europa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-17292-4