SARS-CoV2 envelope protein: non-synonymous mutations and its consequences.
Genomics
; 112(6): 3890-3892, 2020 11.
Article
in English
| MEDLINE | ID: covidwho-632102
ABSTRACT
In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope (E) protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane and C-terminus domains in 15 (0.414%) genomes among 3617 SARS-CoV2 genomes, analyzed. More precisely, 10(0.386%) out of 2588 genomes from the USA, 3(0.806%) from Asia, 1 (0.348%) from Europe and 1 (0.274%) from Oceania contained the missense mutations over the E-protein of SARS-CoV2 genomes. The C-terminus motif DLLV has been to DFLV and YLLV in the proteins from QJR88103 (Australia Victoria) and QKI36831 (China Guangzhou) respectively, which might affect the binding of this motif with the host protein PALS1.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Coronavirus Envelope Proteins
/
SARS-CoV-2
/
COVID-19
/
Mutation
Limits:
Humans
Language:
English
Journal:
Genomics
Journal subject:
Genetics
Year:
2020
Document Type:
Article
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